L9783

Leupeptin hydrochloride

powder, ≥90% (HPLC)

• Synonyme(s) : Acetyl-Leu-Leu-Arg-al hydrochloride
• Formule empirique (notation de Hill) : C₂₀H₃₈N₆O₄ · HCl
• Numéro CAS: 24125-16-4
• Poids moléculaire : 463.01
• UNSPSC Code: 12352202
• PubChem Substance ID: 24896529
• NACRES: NA.77
• MDL number: MFCD00133457

Propriétés

• Nom du produit: Leupeptin hydrochloride, microbial, ≥90% (HPLC)
• biological source: microbial
• Quality Segment: 200
• assay: ≥90% (HPLC)
• form: powder
• input: general use sample(s)
• solubility: water: 50 mg/mL, clear, colorless
• storage temp.: −20°C
• SMILES string: Cl.CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C=O
• InChI: 1S/C20H38N6O4.ClH/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);1H
• InChI key: OQQYPQNFLLAILR-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM.

Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)

Analysis Note

Leupeptin gives multiple peaks on HPLC because of the formation of tautomeric isomers in solution. Majority of contaminating peptide is racemized leupeptin.

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)