L9133

Leucine Enkephalin acetate salt hydrate

≥95% (HPLC), μ- and δ-opioid receptor agonist

• Synonyme(s) : Leucine Enkephalin
• Formule empirique (notation de Hill) : C₂₈H₃₇N₅O₇ · xC₂H₄O₂ · yH₂O
• Poids moléculaire : 555.62 (anhydrous free base basis)
• UNSPSC Code: 12352209
• eCl@ss: 32160409
• PubChem Substance ID: 329817669
• NACRES: NA.32
• MDL number: MFCD11045938

Propriétés

• Nom du produit: Leucine Enkephalin acetate salt hydrate, ≥95% (HPLC)
• Quality Segment: 200
• assay: ≥95% (HPLC)
• storage temp.: −20°C
• SMILES string: O.CC(O)=O.CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc2ccc(O)cc2)C(O)=O
• InChI: 1S/C28H37N5O7.C2H4O2.H2O/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19;1-2(3)4;/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40);1H3,(H,3,4);1H2/t21-,22-,23-;;/m0../s1
• InChI key: QKDIOZBQOQJXFR-XQCXOTTHSA-N
• Gene Information: human ... OPRD1(4985), OPRM1(4988) ; mouse ... OPRD1(18386), OPRM1(18390) ; rat ... OPRD1(24613), OPRM1(25601)

Description

General description

Leucine Enkephalin is a pentapeptide and is a normal component of central and peripheral tissues. Leucine Enkephalin has amino acid sequence Tyr-Gly-Gly-Phe-Leu and is distributed in the brains of many animals, including humans. It is an endogenous opioid neurotransmitter/neuromodulator localized in brain parallels and in δ receptors.

Application

Leucine Enkephalin acetate salt hydrate has been used in the calibration of the Q-Tof Micro hybrid, triple quadrupole-orthogonal acceleration time of flight (TOF) instrument in single-stage TOF mode. It has also been used to perform the calibration of mass spectrometry. It has also been used in liquid chromatography-mass spectrometry (LCMS)/MS for calibration of the system and for relative correction of the spectra.

Biochem/physiol Actions

Leucine Enkephalin (LEU-ENK) functions as agonists at both μ- and δ-opioid receptor sites. It might also play a role as neurotransmitter agent at morphine-sensitive synapses. Leucine Enkephalin is also associated with pain regulation. LEU-ENK expressed in camel lacrimal nerve regulates lacrimal fluid and protein secretion. LEU-ENK is degraded during metabolism by several enzymes, including aminopeptidase-N (APN), neutral endopeptidase (NEP), dipeptidyl peptidase- 3 (DPP3), carboxy peptidase-A6 (CPA-6) and angiotensin converting enzyme (ACE), which are sometimes referred to as enkephalinases.

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)