I6659

Imperatorin

≥98% (HPLC), AChE inhibitor, powder

• Synonyme(s) : 9-[(3-METHYL-2-BUTEN-1-YL)OXY]-7H-FURO[3,2-G][1]BENZOPYRAN-7-ONE
• Formule empirique (notation de Hill) : C₁₆H₁₄O₄
• Numéro CAS: 482-44-0
• Poids moléculaire : 270.28
• NACRES: NA.77
• PubChem Substance ID: 329815395
• UNSPSC Code: 12352200
• EC Number: 207-581-1
• MDL number: MFCD00016881
• Assay: ≥98% (HPLC)
• Form: powder

Propriétés

• Nom du produit: Imperatorin, ≥98% (HPLC), powder
• assay: ≥98% (HPLC)
• form: powder
• color: off-white to light brown
• solubility: DMSO: ≥5 mg/mL
• storage temp.: 2-8°C
• SMILES string: C\C(C)=C\COc1c2OC(=O)C=Cc2cc3ccoc13
• InChI: 1S/C16H14O4/c1-10(2)5-7-19-16-14-12(6-8-18-14)9-11-3-4-13(17)20-15(11)16/h3-6,8-9H,7H2,1-2H3
• InChI key: OLOOJGVNMBJLLR-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Imperatorin is an important bioactive furanocoumarin. It is used to treat neurodegenerative diseases. It possesses anticancer, antibacterial, anti-inflammatory and HIV replication-inhibiting activities. Imperatorin serves as an inhibitor of acetylcholinesterase (AChE) and may help in treating Alzheimer′s disease (AD) and Parkinson′s disease (PD).

Imperatorin is a modulator of p38, ERK pathway.

Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H317,H319,H335
• pcodes: P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• target_organs: Respiratory system
• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)