D0676

Dobutamine hydrochloride

≥98% (TLC), powder, α1, β1 and β2-adrenoceptor agonist

• Synonyme(s) : (±)-3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-β-phenethylamine hydrochloride
• Formule empirique (notation de Hill) : C₁₈H₂₃NO₃ · HCl
• Numéro CAS: 49745-95-1
• Poids moléculaire : 337.84
• NACRES: NA.77
• PubChem Substance ID: 24277772
• UNSPSC Code: 12352116
• EC Number: 256-464-1
• MDL number: MFCD00153795
• Assay: ≥98%
• Form: powder

Propriétés

• Nom du produit: Dobutamine hydrochloride, ≥98%
• Quality Segment: 200
• assay: ≥98%
• form: powder
• originator: Eli Lilly
• storage temp.: 2-8°C
• SMILES string: Cl[H].CC(CCc1ccc(O)cc1)NCCc2ccc(O)c(O)c2
• InChI: 1S/C18H23NO3.ClH/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15;/h4-9,12-13,19-22H,2-3,10-11H2,1H3;1H
• InChI key: BQKADKWNRWCIJL-UHFFFAOYSA-N
• Gene Information: human ... ADRB1(153), ADRB2(154)

Description

Application

Dobutamine hydrochloride has been used:

• to treat mouse embryonic fibroblasts for cell death analysis
• to inhibit TAZ (transcriptional coactivator with PDZ-binding motif)/YAP (Yes-associated protein) of Hippo pathway and study its effect on tumor cell proliferation
• as β1-AR partial agonist to determine its effects on budding of endophilin-mRFP-positive structures by live-cell imaging

Biochem/physiol Actions

Dobutamine is a synthetic catecholamine that stimulate the β1 -adrenoceptor receptor. It exhibits inotropic outcome on the myocardium. Dobutamine elevates contractility and is known to be useful in the condition of low blood pressure.

Features and Benefits

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H302 + H312 + H332,H361fd
• pcodes: P202 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Repr. 2
• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges