C9394

Chlorhexidine digluconate solution

20% in H₂O

• Synonyme(s) : 1,6-Bis(N⁵-[p-chlorophényl]-N¹-biguanido)hexane ; 1,1′-Hexaméthylène bis(5 -p-chlorophényl] biguanide)
• Numéro CAS: 18472-51-0
• NACRES: NA.85
• PubChem Substance ID: 329775206
• UNSPSC Code: 51102829
• MDL number: MFCD00083599

Propriétés

• form: liquid
• Quality Segment: 200
• concentration: 20% in H₂O
• solubility: water: soluble 50 % (w/v)
• density: 1.06 g/mL at 25 °C (lit.)
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria
• mode of action: cell membrane | interferes
• storage temp.: 2-8°C
• SMILES string: OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.Clc1ccc(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(Cl)cc2)cc1
• InChI: 1S/C22H30Cl2N10.2C6H12O7/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*7-1-2(8)3(9)4(10)5(11)6(12)13/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*2-5,7-11H,1H2,(H,12,13)/t;2*2-,3-,4+,5-/m.11/s1
• InChI key: YZIYKJHYYHPJIB-UUPCJSQJSA-N

Description

Application

Chlorhexidine has been used to study how essential oils improve skin antisepsis when combined with chlorhexidine digluconate and is used for skin permeation studies . Chronic rinsing with chlorhexidine has been shown to decrease the saltiness of NaCl and the bitterness of quinine.

Used to study mechanism of membrane dysruption by bis(biguanide) molecules.

Biochem/physiol Actions

Agent antimicrobien cationique à large spectre appartenant à la famille des bis(guanides). Son mode d′action consiste à déstabiliser la membrane externe des bactéries. Il est principalement utilisé comme antiseptique/désinfectant topique pour la cicatrisation des plaies, diverses applications dentaires et le brossage chirurgical.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Light sensitive.

Informations sur la sécurité

• pictograms: GHS05,GHS09
• signalword: Danger
• hcodes: H318,H410
• pcodes: P273 - P280 - P305 + P351 + P338 - P391 - P501
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1
• Classe de stockage: 12 - Non Combustible Liquids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, multi-purpose combination respirator cartridge (US)