C7861

Citalopram hydrobromide

≥98% (HPLC), powder, serotonin uptake inhibitor

• Synonyme(s) : 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide
• Formule empirique (notation de Hill) : C₂₀H₂₁FN₂O · HBr
• Numéro CAS: 59729-32-7
• Poids moléculaire : 405.30
• NACRES: NA.77
• PubChem Substance ID: 24278335
• UNSPSC Code: 12352200
• EC Number: 261-890-6
• MDL number: MFCD02101306
• Assay: ≥98% (HPLC)
• Form: powder

Propriétés

• Nom du produit: Citalopram hydrobromide, ≥98% (HPLC)
• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: powder
• solubility: chloroform: soluble, methanol: soluble
• originator: Forest Labs
• storage temp.: 2-8°C
• SMILES string: Br[H].CN(C)CCCC1(OCc2cc(ccc12)C#N)c3ccc(F)cc3
• InChI: 1S/C20H21FN2O.BrH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;/h4-9,12H,3,10-11,14H2,1-2H3;1H
• InChI key: WIHMBLDNRMIGDW-UHFFFAOYSA-N
• Gene Information: human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363), SLC6A4(6532)

Description

General description

Citalopram is a bicyclic phthalene derivative. It initiates serotonergic activity, which produces antidepressant action. Citalopram hydrobromide reverses memory impairment. It is used to treat obsessive compulsive disorder, panic disorder, sociophobia and premenstrual dysphoric disorder.

Application

Citalopram hydrobromide has been used:

• to examine its effects on sirt mRNA and mammalian sirtuins (SIRT) expression in mice
• to monitor body temperature and antidepressant-like behavioral responses in the forced swim test for rats[1]
• for 5-hydroxytryptamine (5-HT) competition uptake assays

Biochem/physiol Actions

Potent and selective serotonin uptake inhibitor (K_i = 5.4 nM); antidepressant

Features and Benefits

This compound was developed by Forest Labs. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H302,H336,H361d,H412
• pcodes: P202 - P261 - P264 - P273 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 2 - STOT SE 3
• target_organs: Central nervous system
• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)