C4520

Cephalothin sodium salt

• Synonyme(s) : 7-(2-Thienylacetamido)cephalosporanic acid sodium salt, Cephalotin sodium salt
• Formule empirique (notation de Hill): C₁₆H₁₅N₂NaO₆S₂
• Numéro CAS: 58-71-9
• Poids moléculaire : 418.42
• Numéro Beilstein : 4120706
• Numéro CE : 200-394-6
• Numéro MDL: MFCD00072025
• Code UNSPSC : 51282506
• ID de substance PubChem : 24278314
• Nomenclature NACRES : NA.85

Propriétés

• Forme: crystalline powder
• Niveau de qualité: 200
• Spectre d'activité de l'antibiotique: Gram-negative bacteria; Gram-positive bacteria
• Mode d’action: cell wall synthesis | interferes
• Température de stockage: 2-8°C
• Chaîne SMILES: [Na+].CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)Cc3cccs3)C2=O)C([O-])=O
• InChI: 1S/C16H16N2O6S2.Na/c1-8(19)24-6-9-7-26-15-12(14(21)18(15)13(9)16(22)23)17-11(20)5-10-3-2-4-25-10;/h2-4,12,15H,5-7H2,1H3,(H,17,20)(H,22,23);/q;+1/p-1/t12-,15-;/m1./s1
• Clé InChI: VUFGUVLLDPOSBC-XRZFDKQNSA-M

Description

Description générale

Chemical structure: ß-lactam

Application

Cephalothin is a first-generation cephalosporin antibiotic used to study the mechanism of liposome encapsulated antibiotics, strategies for co-opting β-lactamases of Gram-negative bacteria for treatment of antibiotics, and for immunology studies in relation to antibiotics. It is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP6 on bacterial cell wall mucopeptide synthesis.

Actions biochimiques/physiologiques

Mode of Action: Disrupts the synthesis of the peptidoglycan layer of bacterial cell walls.

Antimicrobial spectrum: Effective aginast both Gram-positive and Gram-negative bacteria.

Mode of Resistance: Production of cephalosporinase will inactivate the product.

Autres remarques

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H317,H334
• Conseils de prudence: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• Classification des risques: Resp. Sens. 1 - Skin Sens. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves