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Key Documents

C0984

Sigma-Aldrich

Creatine Kinase MB Fraction from human heart

≥70% (SDS-PAGE), liquid

Synonyme(s) :

CK MB Fraction

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About This Item

Numéro MDL:
MFCD00151686
Code UNSPSC :
12352204
Nomenclature NACRES :
NA.54

Source biologique

human heart

Niveau de qualité

200

Pureté

≥70% (SDS-PAGE)

Forme

liquid

Concentration

≥0.5 mg/mL

Technique(s)

IR spectroscopy: suitable

Adéquation

suitable for tissue

Numéro d'accès UniProt

P06732
P12277

Application(s)

pharmaceutical

Température de stockage

−20°C

Informations sur le gène

human ... CKB(1152) , CKM(1158)

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Description générale

Research area: Cell Signaling
Creatine Kinase (CK) comprises M and B subunit and is a dimeric molecule. It is one among the isoenzymes of CK. The enzyme is majorly present in the myocardium.

Application

Creatine Kinase MB Fraction from human heart has been used:
  • as a diagnostic marker for acute myocardial infarction.
  • to identify overlapping absorbance peaks between blood and the cardiac biomarkers.
  • to study the phosphorylation pathway of dioxolane guanosine (DXG) in vivo, a potential treatment of HIV-1 infection.

Actions biochimiques/physiologiques

Creatine Kinase (CK) catalyzes the formation of creatinine from creatine phosphate. The enzyme is associated with coronary performance. Elevated serum levels of CK-MB are prime indicators of myocardial cellular injury. It is regarded as a “gold standard” for myocardial infarction diagnosis. The levels of cardiac troponin I (cTnI) or cardiac troponin T also correlate to higher CK-MB) levels. CK-MB levels may also be elevated in chronic renal failure.

Composants

Solution in 5 mM sodium succinate, 10 mM sodium chloride, 1 mM EDTA, 5 mM β-mercaptoethanol, 50% glycerol, pH 7.0.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Consulter la Bibliothèque de documents

J E Adams et al.
Clinical chemistry, 40(7 Pt 1), 1291-1295 (1994-07-01)
Although measurement of cardiac troponin I (cTnI) is, in some situations, more specific for detection of cardiac injury than is measurement of the MB isoenzyme of creatine kinase (MBCK), its sensitivity and specificity relative to MBCK for detection of myocardial
Development and preliminary validation of infrared spectroscopic device for transdermal assessment of elevated cardiac troponin
Titus J, et al.
Communications medicine, 2 (2022)
Creatine Kinase
Clinical Methods: The History, Physical, and Laboratory Examinations (1990)
Terry M Welsh et al.
Annals of clinical and laboratory science, 32(1), 44-49 (2002-02-19)
The diagnosis of myocardial infarction (MI) is established in patients with chest pain and equivocal electrocardiogram changes by demonstrating a rise in blood levels of creatine kinase MB (CK-MB) and/or an increase in cardiac troponin I (cTnI) or cardiac troponin
L Gruberg et al.
The American journal of cardiology, 87(12), 1356-1360 (2001-06-09)
We evaluated the short- and long-term clinical outcomes of 326 consecutive patients with chronic renal failure, not on dialysis, who had creatine kinase (CK)-myocardial band (MB) fraction elevation after successful percutaneous coronary intervention in a native coronary artery. Based on
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Chromatograms

application for HPLC

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