ABK0008

InnoBridge ELISA Kit

• Synonyme(s) : ELISA kit
• NACRES: NA.32
• UNSPSC Code: 41116158
• Species reactivity: human (Human IgG)
• Storage temp.: −20°C
• Shipped in: wet ice

Propriétés

• antibody form: IgG fraction of antiserum
• species reactivity: human (Human IgG)
• technique(s): ELISA: suitable
• shipped in: wet ice
• storage temp.: −20°C

Description

General description

A Protein Conformational Array (PCA) in a sandwich ELISA format where the plate is coated with a panel of antibodies raised against peptides derived from the full length protein sequence of seven commercial monoclonal antibody biologic drugs (Biologics). Taken individually, each of these antibodies is strongly antigenic to the peptide sequence that was used in its production. However, when these peptides are incorporated into a full length correctly folded protein, the antigenicity of many of them is masked by the three dimensional structure of the protein and only a limited number of the antibodies respond. The result is a histogram which can be likened to a ‘fingerprint′ for any given monoclonal antibody. Once that ‘fingerprint′ is established, then any changes that occur in that mAb during purification or other manipulations will likely expose a new antigenic site which can be detected by the antibodies on the plate.

Application

For research use only. Not for use in diagnostic procedures.

Informations sur la sécurité

• Pictogrammes: GHS05
• Mot-clé: Warning
• Codes de danger: H290,H315,H319
• Mentions de précaution: P234 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Hazard Classifications: Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2
• Classe de stockage: 10 - Combustible liquids
• Que se passe-t-il ?: WGK 1