A4036

Adenosine

suitable for cell culture, BioReagent

• Synonyme(s) : 9-β-D-Ribofuranosyladenine, Adenine riboside, Adenine-9-β-D-ribofuranoside
• Formule empirique (notation de Hill): C₁₀H₁₃N₅O₄
• Numéro CAS: 58-61-7
• Poids moléculaire : 267.24
• Numéro Beilstein : 93029
• Numéro CE : 200-389-9
• Numéro MDL: MFCD00005752
• Code UNSPSC : 12352207
• eCl@ss : 32160413
• ID de substance PubChem : 24890739
• Nomenclature NACRES : NA.75

Propriétés

• Source biologique: synthetic (organic)
• Gamme de produits: BioReagent
• Pureté: ≥99% (HPLC)
• Forme: powder
• Technique(s): cell culture | mammalian: suitable
• Pf: 234-236 °C (lit.)
• Solubilité: 1 M NH4OH: 50 mg/mL, clear, colorless
• Température de stockage: 2-8°C
• Chaîne SMILES: Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
• InChI: 1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
• Clé InChI: OIRDTQYFTABQOQ-KQYNXXCUSA-N
• Informations sur le gène: human ... ADA(100) , ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140) , ERBB2(2064) , ERBB4(2066) ; rat ... Adcy2(81636) , Adora1(29290) , Adora2a(25369) , Adora3(25370)

Description

Description générale

The nucleoside adenosine consists of the purine adenine and the sugar ribose. Thus, it is also referred as adenine-D-ribose. Adenosine is an important molecule that forms nucleotides, which is a part of nucleic acids forming the DNA and RNA. The nucleotides include: adenosine monophosphate, adenosine diphosphate and adenosine triphosphate.

Application

Adenosine has been used as a supplement in DMEM (Dulbecco′s modified Eagle medium):

• to evaluate the outgrowth of the interspecies somatic cell nucleus transfer (iSCNT)-derived blastocysts
• to maintain the CGR8 ES (germ-line competent cell line) cells
• for plasmid transfection and cloning of embryonic stem cells

Actions biochimiques/physiologiques

Endogenous neurotransmitter at adenosine receptors. Cardioprotective effects may relate to activation of A₁ adenosine receptors. The antiplatelet and anti−inflammatory actions of adenosine appear to be mediated via the A₂ adenosine receptor. In contrast, adenosine appears to be a pro-inflammatory mediator in asthma and chronic obstructive pulmonary disease (COPD).

Tissue injury, ischemia and abnormal cell proliferation stimulate the release of adenosine. Adenosine helps in countering the effects of reduced oxygen and energy in organs such as heart, brain and skeletal muscles mediating vasodialation. It delivers its action through G protein-coupled receptors. Adenosine also reduces the release of neurotransmitters and cellular metabolism.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)