A3487

Clarithromycin

96.0-102.0% (HPLC)

• Synonyme(s) : 6-O-Methylerythromycin
• Formule empirique (notation de Hill): C₃₈H₆₉NO₁₃
• Numéro CAS: 81103-11-9
• Poids moléculaire : 747.95
• Numéro MDL: MFCD00865140
• Code UNSPSC : 51102829
• ID de substance PubChem : 329770825
• Nomenclature NACRES : NA.85

Propriétés

• Source biologique: synthetic
• Niveau de qualité: 200
• Pureté: 96.0-102.0% (HPLC)
• Forme: powder
• Couleur: white to off-white
• Spectre d'activité de l'antibiotique: Gram-negative bacteria; Gram-positive bacteria
• Mode d’action: protein synthesis | interferes
• Température de stockage: 2-8°C
• Chaîne SMILES: O[C@@H]([C@@](O)(C)[C@@H](CC)OC([C@H](C)[C@H]1O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(OC)C2)=O)[C@@H](C)C([C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@H]1C)=O
• InChI: 1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
• Clé InChI: AGOYDEPGAOXOCK-KCBOHYOISA-N

Description

Application

Clarithromycin has been used to study its effect on the potassium channel KCNJ5^WT.

Actions biochimiques/physiologiques

Clarithromycin is stable in gastric acid.

Clarithromycin possess bactericidal activity including anti-mycobacterial activity against Mycobacterium leprae, and M.avium complex.

Clarithromycin is a macrolide antibiotic that interferes with bacterial protein synthesis. Clarithromycin is an acid-stable version of erythromycin and is particularly effective against Gram-negative bacteria. It has a short half-life, however its metabolite, 14-hydroxy clarithromycin is nearly twice as active as clarithromycin against certain bacteria.

Conditionnement

100mg

Notes préparatoires

Practically insoluble in water, soluble in acetone and methylene chloride, slightly soluble in methanol.

Autres remarques

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P301 + P312 + P330
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable