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Merck
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Key Documents

A2487

Sigma-Aldrich

Cotrimoxazole, Ready Made Solution

100 mg/mL in DMSO

Synonyme(s) :

Trimethoprim-Sulfamethoxazole, TMP-SMX

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About This Item

Formule empirique (notation de Hill):
C14H18N4O3 · 5 C10H11N3O3S
Numéro CAS:
8064-90-2
Poids moléculaire :
1556.71
Code UNSPSC :
51102829
Nomenclature NACRES :
NA.85

Forme

liquid

Niveau de qualité

200

Concentration

100 mg/mL in DMSO

Couleur

colorless to faint yellow

Spectre d'activité de l'antibiotique

Gram-negative bacteria
Gram-positive bacteria
fungi
parasites

Mode d’action

DNA synthesis | interferes

Conditions d'expédition

dry ice

Température de stockage

−20°C

InChI

1S/C14H18N4O3.C10H11N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2-6H,11H2,1H3,(H,12,13)

Clé InChI

WZRJTRPJURQBRM-UHFFFAOYSA-N

Application

Cotrimoxazole has been used as an antimicrobial agent.

Actions biochimiques/physiologiques

Cotrimoxazole, a combination of trimethoprim and sulfamethoxazole, interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase (DHFR) which inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF), resulting in an antimicrobial effect. Sulfamethoxazole interferes with the synthesis of nucleic acids in sensitive microorganisms by blocking the conversion of p-aminobenzoic acid to the coenzyme dihydrofolic acid. The net effect of these actions is to inhibit thymidine synthesis which prevents bacterial DNA synthesis.

Conditionnement

1ml

Notes préparatoires

prepared using a 1:5 mixture of trimethoprim:sulfamethoxazole

Autres remarques

Keep container tightly closed in a dry and well-ventilated place.

Pictogrammes

Health hazard
GHS08

Mention d'avertissement

Warning

Mentions de danger

H361fd,H412

Classification des risques

Aquatic Chronic 3 - Repr. 2

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Nada A Elnadi et al.
Journal of the Egyptian Society of Parasitology, 43(2), 457-462 (2013-11-23)
Pneumocystitis may cause fatal pneumonia in premature, seriously ill infants at intensive care units. The present study evaluated the routine treatment applied at Sohag pediatrics department for neonatal and infantile pneumonia (in NICU & PICU) on PCP and to compare
Milind M Baldi et al.
Journal of bronchology & interventional pulmonology, 20(4), 333-337 (2013-10-29)
Pulmonary alveolar proteinosis (PAP) is a rare disease with worldwide distribution and an estimated incidence of 0.36 cases per million. We report a case of a PAP coexisting with Pneumocystis jiroveci pneumonia and Mycobacterium tuberculosis infection. The patient was treated
Ana I Camargo et al.
Biochimica et biophysica acta, 1834(12), 2823-2831 (2013-10-26)
Centrins are calcium-binding proteins associated with microtubules organizing centers. Members of two divergent subfamilies of centrins were found in the aquatic fungus Blastocladiella emersonii, contrasting with the occurrence of only one member known for the better explored terrestrial fungi. BeCen1
Oana Maria Parasca et al.
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 117(2), 558-564 (2013-12-18)
Sulfonamides and their different derivatives are extensively used in therapy due to their pharmacological properties. Sulfa drugs were amongst the oldest synthesized antimicrobial agents and are still widely used today to treat different microbial infections. Clinical treatment with sulfonamides has
Diversity of Escherichia coli strains producing extended-spectrum beta-lactamases in Spain: second nationwide study.
Diaz MA, et al.
Journal of Clinical Microbiology, 48, 2840-2845 (2010)
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