92131

Triméthoprime

≥99.0% (HPLC)

• Synonyme(s) : 2,4-diamino-5-(3,4,5-triméthoxybenzyl)pyrimidine, NSC 106568
• Formule empirique (notation de Hill) : C₁₄H₁₈N₄O₃
• Numéro CAS: 738-70-5
• Poids moléculaire : 290.32
• UNSPSC Code: 51285203
• NACRES: NA.85
• PubChem Substance ID: 57653467
• EC Number: 212-006-2
• Beilstein/REAXYS Number: 625127
• MDL number: MFCD00036761

Propriétés

• biological source: synthetic
• Quality Segment: 200
• assay: ≥99.0% (HPLC)
• form: powder
• color: white to light yellow
• mp: ≥199.0 °C
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria, mycobacteria
• mode of action: DNA synthesis | interferes, enzyme | inhibits
• storage temp.: 2-8°C
• SMILES string: COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
• InChI: 1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
• InChI key: IEDVJHCEMCRBQM-UHFFFAOYSA-N
• Gene Information: human ... DHFRP1(573971), KCNH1(3756) ; rat ... Dhfr(24312)

Description

General description

Chemical structure: pyrimidine

Application

Produit principalement utilisé comme agent antibactérien. Inhibiteur de la dihydrofolate réductase présentant une sélectivité pour l'enzyme procaryote.

Trimethoprim is primarily used as an antibacterial agent. It is used in susceptibility studies of Mycobacterium tuberculosis and mechanism of resistance studies in Haemophilus influenzae .

Biochem/physiol Actions

Inhibits the synthesis of tetrahydrofolate by procaryote specific dihydrofolate reductase (DHFR).

Trimethoprim is a dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.

Packaging

1g,5g,25g

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Light sensitive. Store under inert gas. Moisture sensitive. Product is sensitive to light and moisture.

Informations sur la sécurité

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H302,H361d
• pcodes: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 2
• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)