72309

Acide nicotinique

≥99.5% (HPLC)

• Synonyme(s) : Acide 3-picolinique, Acide pyridine-3-carboxylique, Facteur de prévention de la pellagre
• Formule empirique (notation de Hill) : C₆H₅NO₂
• Numéro CAS: 59-67-6
• Poids moléculaire : 123.11
• UNSPSC Code: 12352209
• NACRES: NA.26
• PubChem Substance ID: 57652411
• EC Number: 200-441-0
• Beilstein/REAXYS Number: 109591
• MDL number: MFCD00006391

Propriétés

• biological source: synthetic
• Quality Segment: 200
• assay: ≥99.5% (HPLC)
• form: powder
• technique(s): cell culture | mammalian: suitable
• impurities: ≤0.2% water
• ign. residue: ≤0.05%
• color: colorless to white
• mp: 234-238 °C, 236-239 °C (lit.)
• solubility: water: 0.1 g/10 mL, clear, colorless
• density: 1.473 g/cm³ at 25 °C
• SMILES string: OC(=O)c1cccnc1
• InChI: 1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
• InChI key: PVNIIMVLHYAWGP-UHFFFAOYSA-N
• Gene Information: human ... CYP1A2(1544) ; rat ... Chrnb2(54239)

Description

General description

Nicotinic acid, also referred as Niacin or vitamin B₃, is a water soluble vitamin. It is present in vitamin-enriched bread, liver, meat, fish, poultry, potatoes, green vegetables, peanuts and cereals.

Application

Nicotinic acid has been used as a standard in NAD⁺ precursor rescue experiments. It has also been used as a vitamin supplement in various culture media such as complete medium (CM) and synthetic medium.

Biochem/physiol Actions

Nicotinic acid or Niacin regulates lipid metabolism by reducing low density lipoprotein (LDL), increasing high-density lipoprotein (HDL) and by inhibiting the progression of atherosclerosis and coronary artery lesions. Niacin deficiency leads to pellagra. In addition to vitamin supplement, niacin is also used as a broad spectrum lipid drug.

Other Notes

Coenzyme and Cofactors, vol 2: Pyridine Nucleotide Coenzymes

Informations sur la sécurité

• pictograms: GHS07
• signalword: Warning
• hcodes: H319
• pcodes: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: 379.4 °F - closed cup
• flash_point_c: 193 °C - closed cup
• ppe: dust mask type N95 (US), Eyeshields, Gloves