Doxorubicin hydrochloride is typically soluble in aqueous solutions, and DPBS provides a buffered environment that maintains pH stability. The absence of calcium and magnesium is generally not a concern for the solubility of doxorubicin, as these ions are not required for its dissolution.
44583
Doxorubicine hydrochloride
suitable for fluorescence, 98.0-102.0% (HPLC)
Synonyme(s) :
DOX, Hydroxydaunorubicine hydrochloride
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| Conditionnement | Référence | Disponibilité | Prix |
|---|
A propos de cet article
Formule empirique (notation de Hill) :
C27H29NO11 · HCl
Numéro CAS:
Poids moléculaire :
579.98
UNSPSC Code:
51281818
NACRES:
NA.76
PubChem Substance ID:
EC Number:
246-818-3
Beilstein/REAXYS Number:
4229251
MDL number:
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synthetic
Quality Segment
assay
98.0-102.0% (HPLC)
form
solid
color
orange to dark red
mp
216 °C (dec.) (lit.)
solubility
H2O: 50 mg/mL, clear, orange to red, DMSO: soluble, THF: soluble, ethanol: soluble, methanol: soluble
fluorescence
λem 580-590 nm
suitability
suitable for fluorescence
antibiotic activity spectrum
neoplastics
mode of action
DNA synthesis | interferes, enzyme | inhibits
storage temp.
2-8°C
SMILES string
Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
InChI
1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
InChI key
MWWSFMDVAYGXBV-RUELKSSGSA-N
Gene Information
human ... TOP2A(7153)
General description
Chemical structure: tetracycline
Application
Biochem/physiol Actions
Doxorubicin ia an antitumor antibiotic that intercalates DNA and inhibits macromolecular biosynthesis. DNA replication is haulted due to the inhibition of topoisomerase II. It is an inhibitor of reverse transcriptase and RNA polymerase and is an immunosuppressive agent [3].
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
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Cet article | |||
|---|---|---|---|
| mode of action DNA synthesis | interferes, enzyme | inhibits | mode of action DNA synthesis | interferes | mode of action - | mode of action - |
| antibiotic activity spectrum neoplastics | antibiotic activity spectrum viruses | antibiotic activity spectrum - | antibiotic activity spectrum - |
| Quality Level 200 | Quality Level 200 | Quality Level 300 | Quality Level - |
| form solid | form powder | form powder | form solid |
| suitability suitable for fluorescence | suitability - | suitability - | suitability - |
| assay 98.0-102.0% (HPLC) | assay 98.0-102.0% (HPLC) | assay - | assay - |
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B
Classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| 44583-1MG | 04061832284132 |
| 44583-50MG | 04061835541379 |
| 44583-10MG | 04061832284118 |
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I would like to ask if it is acceptable to dissolve doxorubicin using Dulbecco’s Phosphate Buffered Saline (DPBS) without Calcium and Magnesium – L0615. Would this buffer be suitable for preparing the doxorubicin solution? Thank you for your help.
1 answer-
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How can I determine the shelf life / expiration / retest date of this product?
1 answer-
If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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Doxorubicin (44583) can dissolve in PBS only or not?
1 answer-
Yes, this product is soluble in water at 50 mg/mL. PBS and other aqueous buffers would also be an option.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the function of Doxorubicin hydrochloride, Product 44583?
1 answer-
In chemotherapy: "Doxorubicin HCl is the hydrochloride salt of doxorubicin, an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin." -National Cancer Institute.
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At what concentration can Doxorubicin hydrochloride, Product 44583, be dissolved in water? At what concentration in DMSO?
1 answer-
The solubility of Product No. 44583 tested in water (50 mg/mL), yielding a clear orange to red solution. It is also soluble in DMSO (50 mg/mL), ethanol, methanol and tetrahydrofuran.
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How stable is a solution of Doxorubicin hydrochloride, Product 44583?
1 answer-
According to the 11th edition of the chemicals encyclopedia published by the Royal Society of Chemistry, "aqueous solutions are unchanged after one month at 5 °C but unstable at higher temperatures or at either acid or alkaline pH. Several studies cite that stability is related to pH, exposure to light and the medium used for storage. Doxorubicin hydrochloride is subject to light degradation at °C in the dark in 5% glucose, pH 4.7 (or 3.3% glucose + 0.3% sodium chloride, pH 4.4), solutions were stable (5% or less change) for at least 4 weeks".
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How should I use Product D1515 - Doxorubicin hydrochloride to induce double strand breaks in the DNA of HeLa cells?
1 answer-
We do not test Product D1515 - Doxorubicin hydrochloride for biological activity with HELA cells. The following paper used 100 nM to 250 nM doxorubicin Adam Hermawan, et al., Journal of Natural Remedies, Vol. 12/2 (2012) 108-114The following paper uses 0.01 to 1.0 mug/ml doxorubicin SH Kim, et al., CANCER RESEARCH 32, 323-325, February 1972
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