AB10140
Anti-Drebrin A/E Antibody
from rabbit, purified by affinity chromatography
Synonyme(s) :
Developmentally-regulated brain protein, drebrin 1, drebrin E, drebrin E2
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Produit purifié par
affinity chromatography
Espèces réactives
rat, human, mouse
Technique(s)
immunocytochemistry: suitable
western blot: suitable
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... DBN1(1627)
Catégories apparentées
Description générale
The developmentally-regulated neuron-specific protein, Drebrin A, is expressed first at the time of outgrowth and maturation of dendrites, and is localized within dendrites of the adult brain. Drebrin E+A- signals have been observed in the cell bodies of migrating neuroblasts in the core region; however, only fibrous and punctate drebrin E+A- signals were observed in postmigratory neuroblasts at the outer layers. Studies have demonstrated that the disappearance of drebrin E+A- signals from the cell body coincides with the cessation of neuronal migration. The disappearance of drebrin E from the cell body may be a molecular switch for the cessation of migration in newly generated neuroblast
Spécificité
Cat. # AB10140 detects the internal domain of Drebrin A/E.
May react with human based on sequence homology. Reactivity with other species has not been determined.
Immunogène
Epitope: Internal Domain
KLH conjugated synthetic linear peptide.
Application
Detect Drebrin A/E using this Anti-Drebrin A/E Antibody validated for use in WB & IC.
Immunocytochemistry: Proven to react with Drebrin A/E in 16 DIV rat cortical neurons. Photo courtesy of Dr. Gang Lui, Drexel University.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Synapse & Synaptic Biology
Synapse & Synaptic Biology
Qualité
Western Blot:
A 1:5,000 dilution of this antibody was used to detect embryonic rat brain (day 16) tissue lysate.
A 1:5,000 dilution of this antibody was used to detect embryonic rat brain (day 16) tissue lysate.
Description de la cible
~77 kDa
Forme physique
Antigen Affinity Purified
Purified rabbit polyclonal antibody in PBS with 0.05% NaN3.
Stockage et stabilité
Stable for 1 year at 2-8ºC from date of receipt.
Remarque sur l'analyse
Control
Embryonic rat brain (day 16) tissue lysate.
Embryonic rat brain (day 16) tissue lysate.
Autres remarques
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Jeffrey H Zimering et al.
PloS one, 11(7), e0159637-e0159637 (2016-07-22)
Early postnatal anesthesia causes long-lasting learning and memory impairment in rodents, however, evidence for a specific neurotoxic effect on early synaptogenesis has not been demonstrated. Drebrin A is an actin binding protein whose localization in dendritic protrusions serves an important
F Ciaffardini et al.
Cell death & disease, 5, e1268-e1268 (2014-05-31)
Cockayne syndrome (CS) is a progressive developmental and neurodegenerative disorder resulting in premature death at childhood and cells derived from CS patients display DNA repair and transcriptional defects. CS is caused by mutations in csa and csb genes, and patients
Kelsie Mozzoni LaBarbera et al.
Journal of neuroscience methods, 358, 109180-109180 (2021-04-10)
Mature primary neuronal cultures are an important model of the nervous system, but limited scalability has been a major challenge in their use for drug discovery of neurodegenerative diseases. This work describes a method for improving scalability through the use
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