8.52011

Fmoc-Leu-OH

Novabiochem^®

• Synonyme(s) : Fmoc-Leu-OH, N-α-Fmoc-L-leucine
• Formule empirique (notation de Hill): C₂₁H₂₃NO₄
• Numéro CAS: 35661-60-0
• Poids moléculaire : 353.41
• Numéro MDL: MFCD00037133
• Code UNSPSC : 12352209
• Numéro de classement CE : 252-662-7
• Nomenclature NACRES : NA.22

Propriétés

• Niveau de qualité: 400
• Gamme de produits: Novabiochem^®
• Pureté: ≥98% (TLC); ≥98.0% (acidimetric); ≥99.0% (HPLC)
• Forme: powder
• Capacité de réaction: reaction type: Fmoc solid-phase peptide synthesis
• Fabricant/nom de marque: Novabiochem^®
• Pf: 145-153 °C
• Application(s): peptide synthesis
• Groupe fonctionnel: Fmoc
• Température de stockage: 2-30°C
• InChI: 1S/C21H23NO4/c1-13(2)11-19(20(23)24)22-21(25)26-12-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h3-10,13,18-19H,11-12H2,1-2H3,(H,22,25)(H,23,24)
• Clé InChI: CBPJQFCAFFNICX-UHFFFAOYSA-N

Description

Description générale

High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities. Standard building block for introduction of leucine amino-acid residues by Fmoc SPPS

Associated Protocols and Technical Articles
Fmoc-amino acids for Peptide Production
Cleavage and Deprotection Protocols for Fmoc SPPS

Application

• Fmoc-protection efficiency: Addressing the efficiency and recrystallization needs in the Fmoc-protection process (R Yoshino et al., 2017).
• Isotopic labeling for NMR: Development of 17O isotopic labeling of N-Formyl-MLF-OH and related building blocks, enhancing NMR spectroscopy applications (M Ha et al., 2021).
• Perovskite solar cell modification: Investigating the role of Fmoc-Leu-OH in modifying perovskite film to enhance solar cell efficiency (J Song et al., 2022).

Liaison

Replaces: 04-12-1025

Remarque sur l'analyse

Colour (visual): white to off white
Appearance of substance (visual): powder
Colour index (0,5 M in DMF): ≤ 150 Hazen
Identity (IR): passes test
Enantiomeric purity: ≥ 99.8 % (a/a)
Purity (HPLC): ≥ 99.0 % (a/a)
Fmoc-ß-Ala-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-ß-Ala-Leu-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-Leu-Leu-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-Ile-OH (GC): ≤ 0.1 % (a/a)
Assay free amino acid (GC): ≤ 0.2 %
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Solubility (25 mmole in 50 ml DMF): clearly soluble
Assay (acidimetric): ≥ 98.0 %
Water (K. F.): ≤ 2.0 %
Ethyl acetate (HS-GC): ≤ 0.5 %
Acetate (IC): ≤ 0.02 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Informations légales

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3