8.14815

Sodium chlorite

(25% solution in water) for synthesis

• Synonyme(s) : Chlorous acid, sodium salt
• NACRES: NA.22
• UNSPSC Code: 12352302
• Grade: synthesis grade
• Form: liquid

Propriétés

• grade: synthesis grade
• Quality Segment: 200
• vapor pressure: 20 hPa ( 20 °C)
• form: liquid
• potency: 1136 mg/kg LD₅₀, oral (Rat)
• reaction suitability: reagent type: oxidant
• pH: 12-13 (20 °C in H₂O)
• bp: ≥100 °C/1013 hPa
• mp: <-3 °C
• density: 1.20-1.25 g/cm³ at 20 °C
• storage temp.: 2-30°C

Description

Application

Sodium chlorite (NaClO₂) can be used as an oxidizing agent for the conversion of:

• Aldehydes to corresponding carboxylic acids under mild reaction conditions in the presence of scavengers such as sulfamic acid or resorcinol.
• Primary alcohols to carboxylic acids in the presence of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and NaOCl.
• Aliphatic and aromatic thiols to the corresponding disulfides.
• Aryl boronic acids to phenols via ipso-hydroxylation.
• Cyclic benzylic ethers and N-protected cyclic benzylic amines to benzolactones and benzolactams.
• Alkenes to epoxides using aldehydes as promoters.
• Alkenes and cycloalkenes to 1, 2 diols via osmium-catalyzed Sharpless asymmetric dihydroxylation.

It can also be used in combination with Br₂ to synthesize 2-carboxyazetidin-2-ones from furanylazetidinones.

Analysis Note

Assay (iodometric): 23.0 - 26.0 %
Density (d 20 °C/ 4 °C): 1.200 - 1.220

Informations sur la sécurité

• Mot-clé: Danger
• Mentions de précaution: P273 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338 - P314
• Organes cibles: spleen
• Que se passe-t-il ?: WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Pictogrammes: GHS06,GHS08,GHS05,GHS09
• Codes de danger: H290,H302,H311,H314,H373,H410
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1 - STOT RE 2
• supp_hazards: EUH032,EUH071
• Classe de stockage: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects