579050

TAPI-0

≥96% (HPLC), solid, collagenase, gelatinase, and TACE inhibitor, Calbiochem^®

• Synonyme(s) : TAPI-0, N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine Amide, TNF-α Protease Inhibitor-0
• Formule empirique (notation de Hill) : C₂₄H₃₂N₄O₅
• Numéro CAS: 143457-40-3
• Poids moléculaire : 456.53
• MDL number: MFCD02684279
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥96% (HPLC)
• Form: solid
• Storage condition: OK to freeze, desiccated (hygroscopic), protect from light

Propriétés

• Nom du produit: TAPI-0, TAPI-0, CAS 143457-40-3, is a hydroxamate-based inhibitor of collagenase, gelatinase, and TACE (TNF-α converting enzyme/ADAM17; IC₅₀ = 100 nM).
• Quality Segment: 100
• assay: ≥96% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic), protect from light
• color: white
• solubility: 50% acetic acid: 1 mg/mL, DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: N(O)C(=O)CC(CC(C)C)C(=O)N[C@@H](Cc1cc2c(cc1)cccc2)C(=O)N[C@@H](C)C(=O)N
• InChI: 1S/C24H32N4O5/c1-14(2)10-19(13-21(29)28-33)23(31)27-20(24(32)26-15(3)22(25)30)12-16-8-9-17-6-4-5-7-18(17)11-16/h4-9,11,14-15,19-20,33H,10,12-13H2,1-3H3,(H2,25,30)(H,26,32)(H,27,31)(H,28,29)/t15-,19?,20-/m0/s1
• InChI key: CRCPLBFLOSEABN-VBSNWNEZSA-N

Description

General description

A hydroxamate-based inhibitor of collagenase, gelatinase, and TACE (TNF-α converting enzyme/ADAM17; IC₅₀ = 100 nM). Blocks spontaneous and PMA-induced release of TNF-α in transfected COS 7 cells.

A hydroxymate-based inhibitor of collagenase, gelatinase, and TACE [(TNF-α convertase; ADAM17 (IC₅₀ = 100 nM)]. Blocks spontaneous and PMA-induced release of TNF-α from transfected COS-7 cells.

Biochem/physiol Actions

Cell permeable: no

Primary Target
TNF-α converting enzyme/ADAM17

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 100 nM against TACE (TNF-α converting enzyme/ADAM17)

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Hooper, N.M., et al. 1997. Biochem. J.321, 265.
Mullberg, J., et al. 1995. J. Immunol.155, 5198.
Mohler, K.M., et al. 1994. Nature370, 218.

Legal Information

Manufactured exclusively by Peptides International, Louisville, Kentucky, USA.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• Que se passe-t-il ?: WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable