557303

Rifampicin

≥97% (HPLC), powder (or crystals), RNA polymerase inhibitor, Calbiochem^®

• Synonyme(s) : Rifampicin, Rifampin, 3-(4-Methylpiperazinyliminomethyl)rifamycin SV
• Formule empirique (notation de Hill) : C₄₃H₅₈N₄O₁₂
• Numéro CAS: 13292-46-1
• Poids moléculaire : 822.94
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00151389
• Assay: ~97-102% (by Assay)
• Form: powder (or crystals)
• Storage condition: OK to freeze

Propriétés

• Nom du produit: Rifampicin, Antibiotic that specifically inhibits DNA-dependent RNA polymerase in bacteria by forming an inactive complex.
• Quality Segment: 100
• assay: ~97-102% (by Assay)
• form: powder (or crystals)
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: red-brown
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: N5(CCN(CC5)C)\N=C\c1c2c(c3c(c4c(c(c3O)C)O[C@](O\C=C\[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]([C@H](\C=C\C=C(/C(=O)N2)\C)C)O)C)O)C)OC(=O)C)C)OC)(C4=O)C)c1O)O
• InChI: 1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1
• InChI key: JQXXHWHPUNPDRT-WLSIYKJHSA-N

Description

General description

Antibiotic that specifically inhibits DNA-dependent bacterial RNA polymerase by forming an inactive complex with RNA polymerase. Does not affect mammalian RNA polymerase. Inhibits transcription by preventing the initial transcription complex from entering the elongation mode.

Biochem/physiol Actions

Primary Target
DNA-dependent RNA polymerase in bacteria

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 2 months at -20°C.

Other Notes

Jin, D.J. and Turnbough, Jr., C.L. 1994. J. Mol. Biol. 236, 72.
Levin, M.E. and Hatfull, G.F. 1993. Mol. Microbiol. 8, 277.
Wehrli, W., et al. 1968. Proc. Natl. Acad. Sci. USA61, 667.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Informations sur la sécurité

• Pictogrammes: GHS07
• Mot-clé: Warning
• Codes de danger: H302
• Mentions de précaution: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Classe de stockage: 11 - Combustible Solids
• Que se passe-t-il ?: WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable