437694

Dihydro-DL-α-Lipoic Acid

≥95% (TLC), NO scavenger, liquid

• Synonyme(s) : DL-α-Lipoic Acid, Dihydro-, DHLA, Dihydrolipoic Acid, Thiocytic Acid, Dihydro-
• Formule empirique (notation de Hill) : C₈H₁₆O₂S₂
• Numéro CAS: 462-20-4
• Poids moléculaire : 208.34
• UNSPSC Code: 12352106
• NACRES: NA.77
• MDL number: MFCD00166974
• Assay: ≥95% (TLC)
• Form: liquid
• Storage condition: OK to freeze, protect from light

Propriétés

• Nom du produit: DL-α-Lipoic Acid, Dihydro-, An effective antioxidant.
• Quality Segment: 100
• assay: ≥95% (TLC)
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: light yellow
• solubility: ethanol: 50 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: SC(CCS)CCCCC(=O)O
• InChI: 1S/C8H16O2S2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H,9,10)
• InChI key: IZFHEQBZOYJLPK-UHFFFAOYSA-N

Description

General description

An effective antioxidant. Scavenges hypochlorous acid, peroxyl, superoxide, hydroxyl, and nitric oxide radicals. Also exhibits prooxidant properties, as demonstrated by its ability to reduce iron ions and to generate reactive sulfur-containing radicals that can damage certain proteins, such as α₁-antiproteinase and creatine kinase. DHLA has recently been shown to inhibit apoptosis in rat thymocytes induced by methylprednisolone and etoposide.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Scavenges hypochlorous acid, peroxyl, superoxide, hydroxyl, and nitric oxide radicals

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Other Notes

Packer, L., et al. 1997. Adv. Pharmacol. 38, 79.
Bustamante, J., et al. 1995. Free Radic. Biol. Med. 19, 339.
Scott, B.C., et al. 1994. Free Radic. Res. 20, 119.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Informations sur la sécurité

• pictograms: GHS05,GHS07,GHS09
• signalword: Danger
• hcodes: H302,H315,H317,H318,H411
• pcodes: P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1
• Classe de stockage: 10 - Combustible liquids
• wgk: WGK 2
• flash_point_f: 348.1 °F - Cleveland open cup
• flash_point_c: 175.6 °C - Cleveland open cup