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345736

Ganglioside GD1a, Disialo, Diammonium Salt, Bovine Brain

Useful as a differentiation marker of tumor cell growth.

Synonyme(s) :

Ganglioside GD1a, Disialo, Diammonium Salt, Bovine Brain, Cer-Glc-Gal(NeuAc)-GalNAc-Gal-NeuAc ·2NH4

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A propos de cet article

Formule empirique (notation de Hill) :
C84H146N4O39 · 2NH4
Poids moléculaire :
1872.14
NACRES:
NA.77
UNSPSC Code:
12352211
Assay:
≥98% (TLC)
Form:
lyophilized
Storage condition:
OK to freeze
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Quality Segment

100

assay

≥98% (TLC)

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

solubility

DMSO: soluble, chloroform/methanol (2:1): soluble

shipped in

ambient

storage temp.

−20°C

General description

Disialoganglioside prepared from bovine gray matter. Useful as a differentiation marker of tumor cell growth. Protein kinase C inhibitor. Readily converted to GM1 by bacterial and mammalian sialidases without detergent or bile salts. One mole yields 2 moles of sialic acid by thiobarbituric acid assay. The molecular weight is based on stearoyl-18:0.



Note: This product is not to be used for animal treatment, in vivo research, or in any other contact procedure with livestock.
Useful as a differentiation marker of tumor cell growth. Protein kinase C inhibitor. Readily converted to GM1 by bacterial and mammalian neuraminidases without detergent or bile salts. Note: the moleculare weight is based on on stearoyl-18:0.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Protein kinase C
Product does not compete with ATP.
Reversible: no

Preparation Note

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
For use in aqueous systems, dissolve in a small amount of DMSO and then sonicate in buffer or medium, or dissolve the dried sample directly in aqueous buffers by sonication. Solutions may be filter sterilized.

Other Notes

Longee, D.C., et al. 1991. Acta Neuropathologica82, 45.
Livingston, P.O., et al. 1987. Proc Natl. Acad. Sci. USA84, 2911.
Kundu, S.K., and Scott, D.D. 1982. J. Chromato.232, 19.
Wakomari, S. 1981. Annu. Rev. Biochem.50, 733.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Classe de stockage

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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