317240

Metformin

≥97% (titration), solid, AMPK signaling activator, Calbiochem^®

• Synonyme(s) : Metformin, 1,1-Dimethylbiguanide, Hydrochloride, AMPK Signaling Activator VII
• Formule empirique (notation de Hill) : C₄H₁₁N₅ · xHCl
• Numéro CAS: 1115-70-4
• Poids moléculaire : 129.16 (free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00012582
• Assay: ≥97% (titration)
• Form: solid
• Storage condition: OK to freeze, desiccated (hygroscopic)

Propriétés

• Nom du produit: Metformin, An antihyperglycemic agent that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia.
• Quality Segment: 100
• description: Merck USA index - 14, 5938
• assay: ≥97% (titration)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic)
• color: white
• solubility: water: 50 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• SMILES string: Cl.N(C)(C)C(=N\C(=N\[H])\N)N
• InChI: 1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H
• InChI key: OETHQSJEHLVLGH-UHFFFAOYSA-N

Description

General description

An anti-hyperglycemic agent that acts by lowering the hepatic output of glucose. Does not stimulate insulin secretion, promote weight gain, or cause hypoglycemia. Reported to stimulate AMP-activated protein kinase (AMPK), leading to the reduction in acetyl-CoA carboxylase (ACC) activity and induction of fatty acid oxidation.

An antihyperglycemic agent that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia. Reported to stimulate AMP-activated protein kinase (AMPK) leading to the reduction in acetyl-CoA carboxylase (ACC) activity and induction of fatty acid oxidation.

Biochem/physiol Actions

Cell permeable: no

Primary Target
AMP-activated protein kinase (AMPK)

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Cleasby, M.E., et al. 2004. Diabetes53, 3258.
Klein, J., et al. 2004. J. Endocrinol.183, 299.
Zhou, G., et al. 2001. J. Clin. Invest.108, 1167.
Lin, H.Z., et al. 2000. Nat. Med.6, 998.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Informations sur la sécurité

• Pictogrammes: GHS07
• Mot-clé: Warning
• Codes de danger: H302,H319
• Mentions de précaution: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2
• Classe de stockage: 11 - Combustible Solids
• Que se passe-t-il ?: WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable