264101

Désoxycholate de sodium

An ionic detergent for the solubilization of membrane-bound proteins.

• Synonyme(s) : Acide 3α,12α-dihydroxy-5β-cholanique sodium salt, Acide 7-désoxycholique sodium salt, Acide désoxycholique sodium salt
• Formule empirique (notation de Hill) : C₂₄H₃₉NaO₄
• Numéro CAS: 302-95-4
• Poids moléculaire : 414.55
• NACRES: NA.21
• UNSPSC Code: 12161902
• Beilstein/REAXYS Number: 3581950
• MDL number: MFCD00064139

Propriétés

• Quality Segment: 100
• description: Merck USA index - 14, 2899
• assay: ≥96% (TLC)
• form: powder
• mol wt: micellar avg mol wt 1200-5000, micellar wt 1700-4200
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic)
• aggregation number: 3-12, 4 - 10
• color: white to off-white
• pKa: 6.2
• CMC: 2-6 mM (20-25°C), 4 - 8 mM
• solubility: H₂O: 2%, clear, colorless
• cation traces: heavy metals: ≤20.0 ppm
• HLB: 16
• shipped in: ambient
• storage temp.: 15-25°C
• SMILES string: [Na+].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@H]([C@H](C)CCC([O-])=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2
• InChI: 1S/C24H40O4.Na/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3;/h14-21,25-26H,4-13H2,1-3H3,(H,27,28);/q;+1/p-1/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-;/m1./s1
• InChI key: FHHPUSMSKHSNKW-SMOYURAASA-M

Description

General description

An ionic detergent for the solubilization of membrane-bound proteins (aggregation number: 4-10; CMC: 4-8 mM; micellar weight: 1700-4200; pKa 6.2). Reported to induce tyrosine phosphorylation of β-catenin and its subsequent translocation to the nucleus, promoting activation of β-catenin signaling (effective concentration 5-50 µM).

Other Notes

Pai, R., et al. 2004. Mol. Biol. Cell15 2156.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

Informations sur la sécurité

• Pictogrammes: GHS07
• Mot-clé: Warning
• Codes de danger: H302
• Mentions de précaution: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Classe de stockage: 11 - Combustible Solids
• Que se passe-t-il ?: WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable