23-027-M
b-catenin Protein, activated, 10 µg
Activated, full length, recombinant human β-catenin. N-terminal c-Myc, 6His-tagged. Phosphorylated in vitro using GSK-3a (Item # 14-492). For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays.
Synonyme(s) :
Catenin beta-1
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About This Item
Code UNSPSC :
12352202
eCl@ss :
32160405
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
human
Niveau de qualité
100
300
Produit recombinant
expressed in Sf21 cells
Fabricant/nom de marque
Upstate®
Technique(s)
activity assay: suitable
Numéro d'accès NCBI
Description générale
β-catenin is a multifunctional protein; it is a central component of the cadherin cell adhesion complex, regulating the control of cell adhesion and plays an essential role in the Wingless/Wnt signaling pathway that governs cell fate in early embryogenesis. The regulation of β-catenin turnover in the cells is governed by its phosphorylation status which allows the targeting of ubiquitin-dependent proteolysis. Altered levels of protein expression as well as genetic mutations of β-catenin have been implicated in a number of human cancers.
N-terminal GST-tagged, recombinant human Smurf1 full length, expressed in E coli.
Application
Ubiquitination Cascade Comoponent: Substrate
Forme physique
Purified using immobilized metal affinity chromatography.
Autres remarques
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Informations légales
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
nwg
Certificats d'analyse (COA)
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?-Catenin signaling is a critical event in ErbB2-mediated mammary tumor progression.
Schade, Babette, et al.
Cancer Research, 73, 4474-4487 (2013)
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