220411

Chenodeoxycholic Acid, Sodium Salt

Bile acid that has been shown to increase intracellular Ca2+ in isolated rat hepatocyte couplets. Induces a permeability transition in freshly isolated rat liver mitochondria.

• Synonyme(s) : Chenodeoxycholic Acid, Sodium Salt
• Formule empirique (notation de Hill) : C₂₄H₃₉O₄ · Na
• Numéro CAS: 2646-38-0
• Poids moléculaire : 414.55
• UNSPSC Code: 12161902
• NACRES: NA.21
• MDL number: MFCD00065452

Propriétés

• Quality Segment: 100
• description: Merck USA index - 14, 2054
• assay: >95% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic)
• color: white
• solubility: water: 20 mg/mL, aqueous buffer: soluble
• cation traces: heavy metals: <10 ppm
• shipped in: ambient
• storage temp.: 15-25°C
• SMILES string: [Na+].[O-]C(=O)CC[C@H]([C@@H]1[C@@]2([C@H]([C@H]3[C@@H]([C@@]4([C@H](C[C@H]3O)C[C@@H](CC4)O)C)CC2)CC1)C)C
• InChI: 1S/C24H40O4.Na/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26;/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28);/q;+1/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-;/m1./s1
• InChI key: WDFRNBJHDMUMBL-OICFXQLMSA-M

Description

General description

Bile acid that has been shown to increase intracellular Ca²⁺ in isolated rat hepatocyte couplets. Induces a permeability transition in freshly isolated rat liver mitochondria.

Other Notes

Rolo, A.P., et al. 2001. Biosci. Rep.21, 73.
Thibault, N., and Ballet, F. 1993. Biochem. Pharmacol. 45, 289.
Roda, A., et al. 1990. J. Lipid Res.31, 1433.
Spivak, W., et al. 1988. Biochem. J.252, 275.
Hisadome, T., et al. 1980. Gastroenterol. Jpn.15, 257.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mot-clé: Danger
• Codes de danger: H301,H361d
• Mentions de précaution: P202 - P264 - P270 - P280 - P301 + P310 - P405
• Hazard Classifications: Acute Tox. 3 Oral - Repr. 2
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable