215921

Chlorpromazine hydrochloride

≥99% (HPLC), calmodulin-dependent phosphodiesterase inhibitor, crystalline solid

• Synonyme(s) : Chlorpromazine, Hydrochloride
• Formule empirique (notation de Hill) : C₁₇H₁₉ClN₂S · xHCl
• Numéro CAS: 69-09-0
• Poids moléculaire : 318.86 (free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00012654
• Assay: ≥99% (HPLC)
• Form: crystalline solid
• Storage condition: OK to freeze, desiccated (hygroscopic)

Propriétés

• Nom du produit: Chlorpromazine, Hydrochloride, Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM).
• Quality Segment: 100
• description: Merck USA index - 14, 2185
• assay: ≥99% (HPLC)
• form: crystalline solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic)
• color: off-white
• solubility: methanol: 10 mg/mL, water: 50 mg/mL
• anion traces: sulfate (SO₄^2-): ≤0.05%
• cation traces: Fe: ≤0.001%, heavy metals: ≤0.002%
• shipped in: ambient
• storage temp.: 10-30°C
• SMILES string: S1c2c(cc(cc2)Cl)N(c3c1cccc3)CCC[N+H](C)C.[Cl-]
• InChI: 1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H
• InChI key: FBSMERQALIEGJT-UHFFFAOYSA-N

Description

General description

Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM). Acts as a peripheral vasodilator. An inhibitor of TNFα production. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in murine lung. Shown to potently and specifically inhibit KSP/Eg5 (IC₅₀<10 µM), and PLA2.

Biochem/physiol Actions

Primary Target
Calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase

Product does not compete with ATP.

Target IC₅₀: 17 µM inhibiting calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase

Preparation Note

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C and for up to 1 week at 4°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

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Yamamoto, H. 1993. Toxicol. Lett. 66, 73.
Vadas, P., et al. 1986. Agents Actions19, 194.
Marshak, P.R., et al. 1985. Biochemistry24, 144.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

Informations sur la sécurité

• Pictogrammes: GHS06
• Mot-clé: Danger
• Codes de danger: H301,H330
• Hazard Classifications: Acute Tox. 1 Inhalation - Acute Tox. 3 Oral
• Classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Mentions de précaution: P260 - P264 - P271 - P284 - P304 + P340 + P310 - P403 + P233