208722

Calpain Inhibitor III

≥95% (HPLC), calpain I and II inhibitor, lyophilized solid

• Synonyme(s) : Calpain Inhibitor III, Carbobenzoxy-valinyl-phenylalaninal, MDL 28170
• Formule empirique (notation de Hill) : C₂₂H₂₆N₂O₄
• Numéro CAS: 88191-84-8
• Poids moléculaire : 382.45
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00798796
• Assay: ≥95% (HPLC)
• Form: lyophilized solid
• Storage condition: OK to freeze

Propriétés

• Nom du produit: Calpain Inhibitor III, The Calpain Inhibitor III, also referenced under CAS 88191-84-8, controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: lyophilized solid
• potency: 8 nM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: DMSO: 20 mg/mL (Use only anhydrous DMSO.)
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: N([C@@H](C(C)C)C(=O)N[C@@H](Cc2ccccc2)C=O)C(=O)OCc1ccccc1
• InChI: 1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19-,20-/m0/s1
• InChI key: NGBKFLTYGSREKK-PMACEKPBSA-N

Description

General description

A potent, cell-permeable inhibitor of calpain I and II (K_i = 8 nM) that also reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effects against glutamate-induced toxicity.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
calpain 1, calpain 2

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Chatterjee, S., et al. 1998. J. Med. Chem.41, 2663.
Rami, A., et al. 1997. Neurosci. Res. 27, 93.
Yamazaki, T., et al. 1997. Biochemistry36, 8377.
Klafki, H., et al. 1996. J. Biol. Chem.271, 28655.
Chard, P.S., et al. 1995. Neuroscience 65, 1099.
Song, D.K., et al. 1994. J. Neurosci. Res. 39, 474.

Z-Val-Phe-CHO

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable