205530

CA-074

CA-074, also referenced under CAS 134448-10-5, modulates the biological activity of cathepsin B. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Synonyme(s) : CA-074, Cathepsin B Inhibitor III, [L-3- trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline
• Formule empirique (notation de Hill) : C₁₈H₂₉N₃O₆
• Poids moléculaire : 383.44
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: OK to freeze

Propriétés

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: colorless to white
• solubility: DMSO: 10 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Description

General description

A potent, irreversible inhibitor of Cathepsin B in vivo and in vitro (IC₅₀ = 2.24 nM for rat liver cathepsin B).

An epoxysuccinyl peptide that acts as a potent, irreversible, and specific inhibitor of cathepsin B (IC₅₀ = 2.24 nM for rat liver cathepsin B). Reduces ischemia-induced neuronal death. Exhibits lower membrane permeability when compared to CA-074 Me (Cat. No. 205531 ).

Biochem/physiol Actions

Cell permeable: no

Primary Target
cathepsin B

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 2.24 nM for rat liver cathepsin B

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Chan, V.J., et al. 1999. Biochem. J. 340, 113.
Tsuchiya, K., et al. 1999. Exp. Neurol. 155, 187.
Yamamoto, A., et al. 1997. J. Biochem.121, 974.
Inubushi, T., et al. 1994. J. Biochem. 116, 282.
Murata, M., et al. 1991. FEBS Lett. 280, 307.
Towatari, T., et al. 1991. FEBS Lett. 280, 311.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• WGK: WGK 3