925136

4,6-Dimethyl-2-(methylsulfinyl)-3-nitropyridine

• Synonyme(s) : 2-Sulfonylpyridine, Cysteine-reactive electrophile, S_NAr probe
• Formule empirique (notation de Hill) : C₈H₁₀N₂O₃S
• Numéro CAS: 2429964-95-2
• Poids moléculaire : 214.24
• MDL number: MFCD16251316
• NACRES: NA.22
• UNSPSC Code: 12352200

Propriétés

• reaction suitability: reagent type: chemical modification reagent
• Quality Segment: 100
• storage temp.: 2-8°C

Description

Application

4,6-Dimethyl-2-(methylsulfinyl)-3-nitropyridine is a sulfoxide-containing fragment for covalent ligand discovery via cysteine labeling as demonstrated by Zamboldo and coworkers. Fragment electrophiles are useful in chemoproteomic and ligandability studies for both traditionally druggable proteins as well as ″undruggable,″ or difficult-to-target, proteins.

Related useful products may include cysteine fragment KB02 (912131), IA alkyne (924237), IA 5-TAMRA (925020), desthiobiotin iodoacetamide (923826), or biotin iodoacetamide (B2059).

Other Notes

2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable