SML1839

PFM39

≥98% (HPLC)

• Synonym(s): (5Z)-2-Amino-5-[(4-aminophenyl)methylene]-4(5H)-thiazolone, 5-(4-Aminobenzylidene)-2-iminothiazolidin-4-one
• Empirical Formula (Hill Notation): C₁₀H₉N₃OS
• CAS Number: 1310744-67-2
• Molecular Weight: 219.26
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: yellow to orange
• solubility: DMSO: 15 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: NC1=CC=C(/C=C2SC(NC\2=O)=N)C=C1
• InChI: 1S/C10H9N3OS/c11-7-3-1-6(2-4-7)5-8-9(14)13-10(12)15-8/h1-5H,11H2,(H2,12,13,14)/b8-5-
• InChI key: QXOIZYPBCJHYLN-YVMONPNESA-N

Description

Biochem/physiol Actions

PFM39 is a potent cell-permeable Mirin analog that selectively inhibits MRE11 exo-, but not endo-, nuclease activity.

PFM39 is a potent cell-permeable Mirin analog that selectively inhibits MRE11 exo-, but not endo-, nuclease activity. PFM39 targets MRE11 in a fashion similar to Mirin, but distinct from that of PFM01 to allow a blockage of dsDNA phosphate backbone rotation and selective inhibition against MRE11 exo-, but not endo-, nuclease activity. FM39 potently impairs G2-phase double-strand break (DSB) repair in 1BR3-hTERT fibrolasts following ionizing irradiation (IR).

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H319
• pcodes: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable