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SML1682

CDN1163

≥98% (HPLC), SERCA activator, powder

Synonym(s):

4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)-benzamide

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About This Item

Empirical Formula (Hill Notation):
C20H20N2O2
CAS Number:
892711-75-0
Molecular Weight:
320.39
UNSPSC Code:
12352200
PubChem Substance ID:
329826012
NACRES:
NA.77
MDL number:
MFCD07177494
Assay:
≥98% (HPLC)
Form:
powder
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Product Name

CDN1163, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

CC1=NC2=C(NC(C3=CC=C(OC(C)C)C=C3)=O)C=CC=C2C=C1

InChI

1S/C20H20N2O2/c1-13(2)24-17-11-9-16(10-12-17)20(23)22-18-6-4-5-15-8-7-14(3)21-19(15)18/h4-13H,1-3H3,(H,22,23)

InChI key

GVGVYDCVFBGALZ-UHFFFAOYSA-N

Biochem/physiol Actions

CDN1163 is an allosteric activator of sarco/ endoplasmic reticulum Ca2+-ATPase (SERCA) that potently lowered fasting blood glucose, improved glucose tolerance and ameliorated hepatosteatosis in ob/ob mice. Additionally CDN1163 induces significant reduction in adipose tissue weight with no change in lean mass in ob/ob mice. CDN1163 has no effect on glucose levels or body weight in lean control mice.
CDN1163 is an allosteric activator of sarco/ endoplasmic reticulum Ca2+-ATPase (SERCA).
CDN1163 treatment declined the hepatic expression of genes implicated in gluconeogenesis and lipogenesis as well as attenuated endoplasmic reticulum (ER) stress response and ER stress-induced apoptosis. CDN1163 interacts with sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) and enhances ER Ca2+ content.

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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Questions

  1. After reconstitution in DMSO, what are the recommended storage conditions and expected stability?

    1 answer

    1. The stability of this material in solution has not been evaluated. For optimum results, stock solutions should be prepared fresh. However, external sources indicate that stock solutions prepared in DMSO, and purged with inert gas, may be stored for up to 1 year at -20°C and up to 2 years at -80°C, in working aliquots. Avoid repeated freeze/thaw cycles. This information has not been validated.

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