Following reconstitution, stock solutions are stable up to 6 months when stored frozen in aliquots at -20°C.
SML0583
Ferrostatin-1
≥95% (HPLC), powder, non-apoptotic cell death inhibitor
Synonym(s):
3-Amino-4-cyclohexylaminobenzoic acid ethyl ester;
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About This Item
Empirical Formula (Hill Notation):
C15H22N2O2
CAS Number:
Molecular Weight:
262.35
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
powder
Pricing and availability is not currently available.
Product Name
Ferrostatin-1, ≥95% (HPLC)
Quality Segment
assay
≥95% (HPLC)
form
powder
color
, faint purple to brown
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
N(C2CCCCC2)c1c(cc(cc1)C(=O)OCC)N
InChI
1S/C15H22N2O2/c1-2-19-15(18)11-8-9-14(13(16)10-11)17-12-6-4-3-5-7-12/h8-10,12,17H,2-7,16H2,1H3
InChI key
UJHBVMHOBZBWMX-UHFFFAOYSA-N
Application
Ferrostatin-1 has been used to determine its inhibitory effect on the cell death profiles.[1]
Biochem/physiol Actions
Ferrostatin-1 is a potent inhibitor of non-apoptotic cell death induced by erastin call ferroptosis.
Ferrostatin-1 is a potent inhibitor of non-apoptotic cell death induced by erastin call ferroptosis. Ferrostatin-1 prevents ferroptopic cell death in cancer cells and glutamate-induced toxicity in organotypic rat brain slices. It appears that Ferrostatin-1 controls lipid soluble ROS.
Ferrostatin-1 is an active radical-trapping antioxidant that traps peroxyl radicals, and thus serves as a potential inhibitor of ferroptosis. Ferroptosis is considered as regulated necrosis, which differs from apoptosis and autophagy. Ferrostatin-1 is known to show protective effects against Huntington′s disease and also prevents neurotoxicity induced by glutamate in cellular models.
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This Item | |||
|---|---|---|---|
| form powder | form solid | form powder | form powder |
| assay ≥95% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥95% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 10 mg/mL, clear | solubility DMSO: soluble >20 mg/mL, H2O: insoluble | solubility DMSO: 10 mg/mL, clear | solubility H2O: 10 mg/mL, clear |
| color , faint purple to brown | color white | color white to beige | color white to beige |
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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DMSOで溶解後の保存は冷蔵保存ですか？それとも冷凍保存でしょうか？
1 answer-
Helpful?
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What is the protocol for diluting SML0583 (5 mg), which is said to be soluble in DMSO? Additionally, what kind of stock solution can I prepare for long-term storage and where to store it after adding DMSO.
1 answer-
The solubility of Ferrostatin-1 is approximately 10 mg/ml in DMSO. The detailed solution stability information is not available; therefore, it is recommended to prepare a fresh solution for each application.
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