SML0539

T863

≥98% (HPLC), DGAT1 inhibitor, powder

• Synonym(s): 2-((1,4-trans)-4-(4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)- phenyl)cyclohexyl)acetic acid, T-863, trans-4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]-cyclohexaneacetic acid
• Empirical Formula (Hill Notation): C₂₂H₂₆N₄O₃
• CAS Number: 701232-20-4
• Molecular Weight: 394.47
• UNSPSC Code: 51111800
• PubChem Substance ID: 329825541
• NACRES: NA.77
• MDL number: MFCD11977270
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: T863, ≥98% (HPLC)
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 15 mg/mL (clear solution)
• storage temp.: 2-8°C
• SMILES string: CC1(C)Oc2ncnc(N)c2N=C1c3ccc(cc3)[C@@H]4CC[C@H](CC4)CC(O)=O
• InChI: 1S/C22H26N4O3/c1-22(2)19(26-18-20(23)24-12-25-21(18)29-22)16-9-7-15(8-10-16)14-5-3-13(4-6-14)11-17(27)28/h7-10,12-14H,3-6,11H2,1-2H3,(H,27,28)(H2,23,24,25)/t13-,14-
• InChI key: FUIYMYNYUHVDPT-HDJSIYSDSA-N

Description

Application

T863 has been used as a diglyceride acyltransferase (DGAT1) inhibitor:

• to provide the opportunity to precisely control the DGAT inhibition
• to treat mouse embryonic fibroblasts (MEFs) to analyse lipid droplet biogenesis
• to specifically block neutral lipid synthesis and lipid droplet formation in HT-1080 cells
• to block lipid droplet (LD) formation

Biochem/physiol Actions

T863 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. T863 causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice.

T863 is an orally active, selective and potent DGAT1 inhibitor.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable