SML0417

Costunolide

≥97% (HPLC)

• Empirical Formula (Hill Notation): C₁₅H₂₀O₂
• CAS Number: 553-21-9
• Molecular Weight: 232.32
• MDL number: MFCD00210262
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825412
• NACRES: NA.77

Properties

• Assay: ≥97% (HPLC)
• form: powder
• optical activity: [α]/D +110.0 to +130.0°, c = 0.5 in chloroform-d
• color: white to beige
• solubility: DMSO: 10 mg/mL (clear solution)
• storage temp.: −20°C
• SMILES string: C\C1=C/CC\C(C)=C\[C@H]2OC(=O)C(=C)[C@@H]2CC1
• InChI: 1S/C15H20O2/c1-10-5-4-6-11(2)9-14-13(8-7-10)12(3)15(16)17-14/h5,9,13-14H,3-4,6-8H2,1-2H3/b10-5+,11-9+/t13-,14+/m0/s1
• InChI key: HRYLQFBHBWLLLL-AHNJNIBGSA-N

Description

General description

Costunolide has anti-ulcer and antipyretic properties. It inhibits the cellular proliferation of melanin, human lamin-B by farnesyl-protein transferase (FPTase) and protein tyrosine phosphatase 1B (hPTP1B). Costunolide has strong larvicidal activity against A.albopictus. It inhibits the expression of inducible nitric oxide synthase and DNA-binding activity of nuclear factor kappa B subunit (NF-κB). It might function as a natural herbicide.

Application

Costunolide has been used to study its effects in allergic asthma using female Balb/c mice and rat basophilic leukemia (RBL)-2H3 mast cells.

Biochem/physiol Actions

Costunolide is a sesquiterpene lactone originally isolated from plants widely used in many herbal medicines. It has a variety of effects. Costunolide is a potent inducer of apoptosis, a potent anti-cancer agent, has anti-inflammatory, anti-viral, anti-fungal, antimycobacterial activity and has been shown to inhibit telomerase activity.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H317
• Precautionary Statements: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable