Skip to Content
Merck
All Photos(1)

Documents

SAB4301170

Sigma-Aldrich

Anti-pan-AKT antibody produced in rabbit

affinity isolated antibody

Synonym(s):

PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA

Sign Into View Organizational & Contract Pricing


About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

56 kDa

species reactivity

rat, human, mouse

concentration

2 mg/mL

technique(s)

western blot: 1:500-1:1000 (Cell Lysate)

isotype

IgG

accession no.

NP_001014431.1

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... AKT1(207)

General description

AKT serine/threonine kinase 1 (AKT1) also called as v-akt murine thymoma viral oncogene homolog 1 or protein kinase B α (PKB α) is encoded by the gene mapped to human chromosome 14q32. It is highly expressed in liver, muscle and adipocytes. The encoded protein is a member of AKT family, which is characterized with an amino-terminal pleckstrin homology (PH) domain, a short α-helical linker and a carboxyl-terminal kinase domain.

Specificity

The antibody detects endogenous levels of total pan-AKT protein.

Immunogen

Synthetic peptide corresponding to a region derived from internal residues of human RAC-alpha serine/threonine-protein kinase

Application

Anti-pan-AKT antibody produced in rabbit has been used in immunoblotting.

Biochem/physiol Actions

AKT serine/threonine kinase 1 (AKT1) acts as a regulator for cell-survival and anti-apoptotic actions which are involved in development of various cancers. This protein has a crucial role in tumorigenesis. In mice, AKT1 is essential for normal development. Mutations in the gene are associated with the pathogenesis of prostate cancer (PC). Elevated expression of the gene has been observed in human gastric cancer. Aberrations in the AKT1 and glycogen synthase kinase 3 (GSK3)-β signaling leads to the development of schizophrenia.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice.
Cho H, et al.
The Journal of Biological Chemistry, 276, 38349-38352 (2001)
Tctex1d2 Is a Negative Regulator of GLUT4 Translocation and Glucose Uptake
Shimoda Y, et al.
Endocrinology, 156, 3548-3558 (2015)
Association between single nucleotide polymorphisms in AKT1 and the risk of prostate cancer in the Chinese Han population.
Liu JM, et al.
Genetics and molecular research : GMR, 16 (2017)
Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia.
Emamian ES, et al.
Nature Genetics, 36, 131-137 (2004)
Noriyasu Kamei et al.
Scientific reports, 8(1), 17641-17641 (2018-12-07)
In a recent study, we demonstrated the potential of a cell-penetrating peptide (CPP) penetratin to deliver the peptide drug insulin to the brain via nasal administration, and its pharmacological effect on the mild cognitive dysfunction in senescence-accelerated mouse (SAMP8). However

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service