S9549
Superoxide dismutase–polyethylene glycol from bovine erythrocytes
lyophilized powder, ≥1,350 units/mg protein
Synonym(s):
PEG-SOD
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About This Item
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form
lyophilized powder
Quality Level
200
400
specific activity
≥1,350 units/mg protein
mol wt
5000 Da
composition
Protein, ≥20% biuret
extent of labeling
≥10 mol PEG per mol protein
storage temp.
−20°C
General description
Superoxide dismutase from bovine erythrocytes is a copper and zinc superoxide dismutase. Copper and zinc ions are coordinated by active site histidine residues. It has β-barrel structure.
Application
Superoxide dismutase-polyethylene glycol from bovine erythrocytes has been used:
- in the incubation of lung slices for measurement of dihydroethidium (DHE) fluorescence in cultured bovine pulmonary artery endothelial cells
- as supplement in T cell culture to investigate its effect on cytokine production
- in the preincubation of the carotid artery sections prior to DHE treatment
Biochem/physiol Actions
Superoxide dismutase-polyethylene glycol (SOD-PEG) is effective than SOD in scavenging free radicals in injuries. It reduces oxidative damage in ovarian follicles cell culture and during ovarian tissue transplantation. SOD-PEG is also effective in scavenging superoxide in mitochondrial abnormalities.
Packaging
Package size based on protein content
Other Notes
Superoxide dismutase from bovine erythrocytes coupled to methoxy-polyethylene glycol, M.W. 5,000, through secondary amine linkage.
Physical form
Lyophilized powder containing PEG plus 5% citrate buffer salts
Preparation Note
Enzyme derived
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Resp. Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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