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L3262

Sigma-Aldrich

Anti-Lactoferrin antibody produced in rabbit

fractionated antiserum, lyophilized powder

Synonym(s):

Anti-Draculin, Anti-Draculin-1

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About This Item

MDL number:
MFCD00162524
UNSPSC Code:
12352203
NACRES:
NA.46

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

fractionated antiserum

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

packaging

vial of 2 mL lyophilized antiserum

technique(s)

direct ELISA: 1:10,000 using using human lactoferrin

UniProt accession no.

P02788

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... LTF(4057)

General description

Lactoferrin, globular glycoprotein belongs to transferrin protein family. It is mapped to human chromosome 3p21.31. Lactoferrin comprises 692 amino acids with two globular lobes linked by α-helix and belongs to transferrin family. It exists in three isoforms namely lactoferrin-α, lactoferrin-γ, and lactoferrin-β. Lactoferrin corresponds to a molecular weight of 80 kDa.

Specificity

Rabbit polyclonal anti-lactoferrin antibody reacts with purified lactoferrin and human milk, but does not react with human serum proteins.

Application

Anti-Lactoferrin antibody produced in rabbit has been used in:
  • western blotting
  • indirect immunofluorescence
  • flow cytometry
  • enzyme-linked immunosorbent assay (ELISA)

Biochem/physiol Actions

A primary function of lactoferrin is to bind and transport iron ions. However, lactoferrin is also an effective antibacterial, antiviral, antiparasitic, catalytic (RNA degrading), anti-cancer molecule. It elicits anti-inflammatory effects in asthma. It has immunomodulatory and anti-inflammatory functionality and is a potential protein nutraceutical.

Physical form

Lyophilized from 0.01 M phosphate buffered saline, pH 7.2

Reconstitution

Reconstitute with 2 ml deionized water.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Genetic and epigenetic inactivation of LTF gene at 3p21. 3 in lung cancers
Iijima H, et al.
International Journal of Cancer. Journal International Du Cancer, 118(4), 797-801 (2006)
Studying lactoferrin N-glycosylation
Karav S, et al.
International Journal of Molecular Sciences, 18(4), 870-870 (2017)
Allergens induce the release of lactoferrin by neutrophils from asthmatic patients
Fernandez-Delgado L, et al.
Testing, 10(10), e0141278-e0141278 (2015)
Neutrophil extracellular traps contain selected antigens of anti-neutrophil cytoplasmic antibodies
Panda R, et al.
Frontiers in Immunology, 8(2), 439-439 (2017)
Napoleon Waszkiewicz et al.
Folia histochemica et cytobiologica, 50(2), 248-254 (2012-07-06)
Salivary lactoferrin is a glycoprotein involved in the elimination of pathogens and the prevention of massive overgrowth of microorganisms that affect oral and general health. A high concentration of lactoferrin in saliva is often considered to be a marker of
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