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E9145

Sigma-Aldrich

Estrone 3-sulfate potassium salt

≥98%

Synonym(s):

1,3,5(10)-Estratrien-17-one 3-sulfate

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About This Item

Linear Formula:
C18H21O5SK
CAS Number:
Molecular Weight:
388.52
EC Number:
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥98%

form

powder

contains

~35% Tris as stabilizer

color

off-white to light tan

solubility

methanol: 9.80-10.20 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

−20°C

SMILES string

[K].[H][C@]12CC[C@]3(C)C(=O)CC[C@@]3([H])[C@]1([H])CCc4cc(OS(O)(=O)=O)ccc24

InChI

1S/C18H22O5S.K.H/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;;/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);;/t14-,15-,16+,18+;;/m1../s1

InChI key

XFQXTMKDDYWSBS-DLEHHZMWSA-N

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Biochem/physiol Actions

The most abundant estrogen in adult human circulation. Conversion to estradiol requires steroid sulfatase activity. This activity was used to evaluate freshly resected bone fragments against cultured osteoblasts and osteosearcoma cells as models for studying human bone metabolism.

Packaging

Package size based on steroid content

Pictograms

Health hazardExclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Repr. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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L M M C Sousa et al.
Placenta, 33(10), 788-794 (2012-07-31)
Our objectives were to investigate the possible role of VEGFA in bovine placenta steroid synthesis and to determine whether cloned derived placental cells present similar responses as non-cloned ones. Placental cells from cloned (term) and non-cloned (days 90, 150, 210
Anna Koenen et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 47(4), 774-780 (2012-09-18)
Previously, the steroid hormone progesterone has been demonstrated to stimulate OATP2B1-mediated transport of estrone-3-sulphate (E(1)S), dehydroepiandrosterone sulphate (DHEAS) and pregnenolone sulphate (PS), which may influence the uptake of precursor molecules for steroid hormone synthesis. However, it is unclear whether OATP2B1
Elizabeth J Folkerd et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 30(24), 2977-2980 (2012-07-18)
To investigate whether suppression of plasma estradiol and estrone sulfate levels by the aromatase inhibitors (AIs) anastrozole and letrozole is related to body mass index (BMI) in postmenopausal women with early estrogen receptor (ER) -positive breast cancer. Recent studies have
Maria Karlgren et al.
Journal of medicinal chemistry, 55(10), 4740-4763 (2012-05-01)
The hepatic organic anion transporting polypeptides (OATPs) influence the pharmacokinetics of several drug classes and are involved in many clinical drug-drug interactions. Predicting potential interactions with OATPs is, therefore, of value. Here, we developed in vitro and in silico models
Anett Engel et al.
Molecular pharmaceutics, 9(9), 2577-2581 (2012-07-20)
Although pharmaceutical excipients are supposed to be pharmacologically inactive, solubilizing agents like Cremophor EL have been shown to interact with cytochrome P450 (CYP)-dependent drug metabolism as well as efflux transporters such as P-glycoprotein (ABCB1) and multidrug resistance associated protein 2

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