A6402

[Asn¹, Val⁵]-Angiotensin II

≥97% (HPLC)

• Empirical Formula (Hill Notation): C₄₉H₇₀N₁₄O₁₁
• CAS Number: 20071-00-5
• Molecular Weight: 1031.17
• MDL number: MFCD00167643
• UNSPSC Code: 12352209
• PubChem Substance ID: 329770893
• NACRES: NA.32

Properties

• Quality Level: 200
• Assay: ≥97% (HPLC)
• form: powder
• storage temp.: −20°C
• SMILES string: CC(C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(O)=O
• InChI: 1S/C49H70N14O11/c1-26(2)39(61-42(67)33(12-8-18-55-49(52)53)57-41(66)32(50)23-38(51)65)45(70)58-34(20-29-14-16-31(64)17-15-29)43(68)62-40(27(3)4)46(71)59-35(22-30-24-54-25-56-30)47(72)63-19-9-13-37(63)44(69)60-36(48(73)74)21-28-10-6-5-7-11-28/h5-7,10-11,14-17,24-27,32-37,39-40,64H,8-9,12-13,18-23,50H2,1-4H3,(H2,51,65)(H,54,56)(H,57,66)(H,58,70)(H,59,71)(H,60,69)(H,61,67)(H,62,68)(H,73,74)(H4,52,53,55)/t32-,33-,34-,35-,36-,37-,39-,40-/m0/s1
• InChI key: JYPVVOOBQVVUQV-CGHBYZBKSA-N
• Gene Information: human ... AGTR1(185) ; mouse ... AGTR1(11607) ; rat ... AGTR1(24180)

Description

Amino Acid Sequence

Asn-Arg-Val-Tyr-Val-His-Pro-Phe

General description

Angiotensin II is a renin-angiotensin system (RAS) effector molecule, which binds to angiotensin II type-1 (AT₁R) and angiotensin II type-2 (AT₂R) receptors.[1] The gene is located on human chromosome 3q24.[2] Angiotensin II is mainly expressed in vessel walls, lung and kidney.[3]

Application

[Asn¹, Val⁵]-Angiotensin II has been used:

• to study the effects of ACTH, serotonin, Ang II, carbachol and elevated [K⁺] on catecholamine and serotonin release[4]
• to induce cyclophilin D (CypD)–dependent mitochondrial vascular superoxide (O2^{. -} ) production in hypertension[5]
• to increase the homocysteine-induced ER stress-inducible, ubiquitin-like domain member 1 (HERPUD1) protein level in HeLa cells[6]

Biochem/physiol Actions

Angiotensin II functions as a vasoconstrictor and controls cardiovascular function.[7] It maintains water-sodium homeostasis, modulates cellular proliferation and vascular remodelling of renin-angiotensin system.[8] Angiotensin II has inflammatory effects.[1]

Synthetic angiotensin agonist that is involved in the regulation of blood pressure, water consumption, and hydromineral balance in fish.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable