30020

D-Cycloserine

• Synonym(s): R-4-Amino-3-isoxazolidinone, (R)-4-Amino-3-isoxazolidone, 4-Amino-3-isoxazolidinone
• Empirical Formula (Hill Notation): C₃H₆N₂O₂
• CAS Number: 68-41-7
• Molecular Weight: 102.09
• Beilstein: 80798
• EC Number: 200-688-4
• MDL number: MFCD00005353
• UNSPSC Code: 51102829
• PubChem Substance ID: 57648401
• NACRES: NA.85

Properties

• biological source: synthetic
• Quality Level: 100
• form: powder
• potency: ≥900 μg per mg
• color: white to off-white
• mp: 147 °C (dec.) (lit.)
• antibiotic activity spectrum: Gram-negative bacteria; Gram-positive bacteria; mycobacteria
• Mode of action: cell wall synthesis | interferes
• storage temp.: −20°C
• SMILES string: N[C@@H]1CONC1=O
• InChI: 1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1
• InChI key: DYDCUQKUCUHJBH-UWTATZPHSA-N

Description

General description

Chemical structure: amino acid derivatives

Application

D-Cycloserine acts as inhibitor of various enzymes.

Biochem/physiol Actions

Mode of Action: Inhibits cell wall biosynthesis (D-Ala peptide bond formation). Also prevents conversion of D-Ala to L-Ala. Bacteriostatic. Mode of Resistance: D-Ala transport interference.

Mode of Action: Inhibits cell wall biosynthesis (D-Ala peptide bond formation). Also prevents conversion of D-Ala to L-Ala. Bacteriostatic.
Partial agonist at the glycine modulatory site of NMDA glutamatergic receptors; antibiotic against Gram-negative bacteria.
Mode of Resistance: D-Ala transport interference.

Packaging

1g, 5g, 25g

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Air sensitive. Keep in a dry place.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves