10385

Angiotensin III trifluoroacetate salt hydrate

≥98% (HPCE)

• Synonym(s): Des-Asp-1-Angiotensin II trifluoroacetate salt hydrate
• Empirical Formula (Hill Notation): C₄₆H₆₆N₁₂O₉ · xC₂HF₃O₂ · yH₂O
• CAS Number: 12687-51-3
• Molecular Weight: 931.09 (anhydrous free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.77
• PubChem Substance ID: 57646800
• MDL number: MFCD20264812
• Beilstein/REAXYS Number: 8385695
• Assay: ≥98% (HPCE)

Properties

• Quality Segment: 100
• assay: ≥98% (HPCE)
• solubility: H₂O: 1.0 mg/mL, clear, colorless
• storage temp.: −20°C
• SMILES string: O.OC(=O)C(F)(F)F.CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(O)=O
• InChI: 1S/C46H66N12O9.C2HF3O2.H2O/c1-5-27(4)38(57-40(61)33(21-29-15-17-31(59)18-16-29)53-42(63)37(26(2)3)56-39(60)32(47)13-9-19-51-46(48)49)43(64)54-34(23-30-24-50-25-52-30)44(65)58-20-10-14-36(58)41(62)55-35(45(66)67)22-28-11-7-6-8-12-28;3-2(4,5)1(6)7;/h6-8,11-12,15-18,24-27,32-38,59H,5,9-10,13-14,19-23,47H2,1-4H3,(H,50,52)(H,53,63)(H,54,64)(H,55,62)(H,56,60)(H,57,61)(H,66,67)(H4,48,49,51);(H,6,7);1H2/t27-,32-,33-,34-,35-,36-,37-,38-;;/m0../s1
• InChI key: JEOAJMGVSAMVML-UFPGTABSSA-N

Description

General description

Angiotensin III (Ang III) is a 7-AA bioactive peptide that is formed from the degradation of the Angiotensin II peptide by aminopeptidase A; both are derivatives of angiotensinogen and are components of the renin-angiotensin system (RAS).

Arg-Val-Tyr-Ile-His-Pro-Phe-OH.3CH₃COOH.4H₂O

Biochem/physiol Actions

Angiotensin III is an AT₁ and AT₂ agonist, with higher sensitivity for the AT₂ receptor. Ang III has been shown to be a main effector peptide in RAS-controlled vasopresin release and a stimulator for aldosterone release.

Features and Benefits

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)