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I1762

Supelco

Isoxicam

analytical standard

Synonym(s):

4-Hydroxy-2-methyl-N-5-methyl-3-isoxolyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide

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About This Item

Empirical Formula (Hill Notation):
C14H13N3O5S
CAS Number:
34552-84-6
Molecular Weight:
335.34
EC Number:
252-084-5
MDL number:
MFCD00079374
UNSPSC Code:
41116107
PubChem Substance ID:
329815356
NACRES:
NA.24

grade

analytical standard

Quality Level

200

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

CN1C(C(=O)Nc2cc(C)on2)=C(O)c3ccccc3S1(=O)=O

InChI

1S/C14H13N3O5S/c1-8-7-11(16-22-8)15-14(19)12-13(18)9-5-3-4-6-10(9)23(20,21)17(12)2/h3-7,18H,1-2H3,(H,15,16,19)

InChI key

YYUAYBYLJSNDCX-UHFFFAOYSA-N

Gene Information

human ... PTGS1(5742) , PTGS2(5743)

General description

Isoxicam is a long acting anti-inflammatory agent belonging to the oxicam group, and helps in relieving the symptoms of degenerative joint disease and rheumatoid arthritis. Its mode of action involves the ability to inhibit prostaglandin synthesis by suppressing the formation of cyclooxygenase and subsequent prostaglandin.

Application

Isoxicam may be used as an internal standard for the quantification of meloxicam in pharmaceutical preparations and as an analytical reference standard for the quantification of the analyte in biological samples using different analytical techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
127F0579

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A review of HPLC methods used for determining the presence of meloxicam
Brezovska M, et al.
Current Pharmaceutical Analysis, 9(1), 69-76 (2013)
W Frankhof
Current medical research and opinion, 11(1), 28-33 (1988-01-01)
The therapeutic efficacy and tolerability of a new controlled-release 1000 mg tablet of naproxen (naproxen CR) were compared with 200 mg isoxicam in 100 out-patients with osteoarthritis. Medications were administered once daily for 4 weeks in a controlled, randomized, double-blind
H Fenner
European journal of rheumatology and inflammation, 9(2), 3-7 (1987-01-01)
The chronicity of the inflammatory process requires persistent tissue concentrations of non-steroidal anti-inflammatory drugs (NSAIDs), best achieved by using a drug with a long half-life as a once-daily regimen. The oxicams proved to be one of the most promising classes
H Fenner
Scandinavian journal of rheumatology. Supplement, 65, 97-101 (1987-01-01)
The chronicity of the inflammatory process requires persistent tissue concentrations of non-steroidal anti-inflammatory drugs (NSAIDs), best achieved by using a drug with a long half-life as a once-daily regimen. The oxicams proved to be one of the most promising classes
T F Woolf et al.
Xenobiotica; the fate of foreign compounds in biological systems, 19(12), 1369-1377 (1989-12-01)
1. Disposition studies in vivo in animals and man indicate that hydroxylation of the isoxazole methyl group of isoxicam is the major route of metabolism. 2. Recently, N-methylsaccharin, saccharin, and an open-ring sulphonamide have been identified as additional isoxicam metabolites.
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