218759

Caspase-8 Inhibitor II

≥98% (HPLC), powder, Caspase-8 inhibitor, Calbiochem^®

• Synonym(s): Caspase-8 Inhibitor II, Z-IE(OMe)TD(OMe)-FMK, Granzyme B Inhibitor III
• Empirical Formula (Hill Notation): C₃₀H₄₃FN₄O₁₁
• Molecular Weight: 654.68
• UNSPSC Code: 12352200
• NACRES: NA.77
• Form: powder
• Storage condition: OK to freeze, desiccated

Properties

• Product Name: Caspase-8 Inhibitor II, The Caspase-8 Inhibitor II controls the biological activity of Caspase-8. This small molecule/inhibitor is primarily used for Cancer applications.
• Quality Segment: 100
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated
• color: white to yellow
• solubility: DMSO: 10 mM
• shipped in: ambient
• storage temp.: −20°C

Description

General description

A potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/76 µl) solution of Z-IETD-FMK (Cat. No. 218840 ) in DMSO is also available.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
caspase-8

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 8 months at -20°C.

Analysis Note

≥98% (HPLC)

Other Notes

Takizawa, T., et al. 1999. Microbiol. Immunol.43, 245.
Martin, D.A., et al. 1998. J. Biol. Chem.273, 4345.
Sweeney, E.A., et al. 1998. FEBS Lett.425, 61.
Thornberry, N.A., and Lazebnik, Y. 1998. Science281, 1312.

Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F*

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable