1.00397

N,N-Dimethylformamide

for peptide synthesis

• Synonym(s): DMF, N,N-Dimethylmethanamide, Formic acid dimethylamide, DMF, NSC 5356
• Linear Formula: HCON(CH₃)₂
• CAS Number: 68-12-2
• Molecular Weight: 73.09
• UNSPSC Code: 12352111
• NACRES: NA.22
• EC Index Number: 200-679-5
• MDL number: MFCD00003284
• Beilstein/REAXYS Number: 605365
• Assay: ≥99.9% (GC)
• Bp: 153 °C (lit.)
• Vapor pressure: 2.7 mmHg ( 20 °C)

Properties

• Quality Segment: 200
• vapor density: 2.5 (vs air)
• vapor pressure: 2.7 mmHg ( 20 °C)
• assay: ≥99.9% (GC)
• form: liquid
• autoignition temp.: 833 °F
• potency: 3010 mg/kg LD₅₀, oral (Rat), 1500 mg/kg LD₅₀, skin (Rabbit)
• expl. lim.: 15.2 %
• dilution: (for synthesis)
• impurities: ≤0.0002 meq/g Alkalinity, ≤0.0005 meq/g Acidity, ≤10 ppm Amines (Dimethylamine), ≤300 ppm Water
• color: APHA: ≤10
• refractive index: n20/D 1.430 (lit.)
• pH: 7 (20 °C, 200 g/L in H₂O)
• bp: 153 °C (lit.)
• mp: −61 °C (lit.)
• transition temp: flash point 57.5 °C
• solubility: soluble 1000 g/L
• density: 0.944 g/mL (lit.)
• application(s): peptide synthesis
• storage temp.: 2-30°C
• SMILES string: [H]C(=O)N(C)C
• InChI: 1S/C3H7NO/c1-4(2)3-5/h3H,1-2H3
• InChI key: ZMXDDKWLCZADIW-UHFFFAOYSA-N

Description

Application

Solvent for many hydrophobic organic compounds.

Analysis Note

Purity (GC): ≥ 99.9 %
Identity (IR): conforms
Color: ≤ 10 Hazen
Acidity: ≤ 0.0005 meq/g
Alkalinity: ≤ 0.0002 meq/g
Amines (Dimethylamine): ≤ 10 ppm
Evaporation residue: ≤ 10
Water: ≤ 300 ppm

Safety Information

• Signal Word: Danger
• Precautionary Statements: P210 - P280 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 1B
• Storage Class: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point (°F): 135.5 °F - closed cup
• Flash Point (°C): 57.5 °C - closed cup
• Pictograms: GHS02,GHS08,GHS07
• Hazard Codes: H226,H312 + H332,H319,H360D