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637637

Sigma-Aldrich

3-Chloro-6-methylpyridazine

97%

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About This Item

Empirical Formula (Hill Notation):
C5H5ClN2
CAS Number:
1121-79-5
Molecular Weight:
128.56
MDL number:
MFCD00052905
UNSPSC Code:
12352100
PubChem Substance ID:
24882876
NACRES:
NA.22

Assay

97%

form

solid

mp

58-62 °C

functional group

chloro

SMILES string

Cc1ccc(Cl)nn1

InChI

1S/C5H5ClN2/c1-4-2-3-5(6)8-7-4/h2-3H,1H3

InChI key

PRORLQAJNJMGAR-UHFFFAOYSA-N

Application

3-Chloro-6-methyl pyridazine can undergo nickel catalyzed cross coupling reaction with aromatic and heteroaromatic halides, to give the corresponding substituted aryl- and heteroaryl pyridazines. It can also be used in the synthesis of a p38MAP kinase inhibitor with therapeutic potential in the treatment of autoimmune and inflammatory diseases.

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H302,H315,H317,H318

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCH8757
MKCD2903
MKBK2021V
MKBJ4701V
MKBD8051V

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Sengmany S, et al.
The Journal of Organic Chemistry, 72(15), 5631-5636 (2007)
"Development of a Practical and Scalable Synthesis of a Potent p38 Mitogen-Activated Protein Kinase Inhibitor"
Yoshida S, et al.
The Journal of Organic Chemistry, 16(11), 1818-1826 (2012)

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