Y4895

YM-58483

≥98% (HPLC)

• Synonyme(s) : 4-methyl-4′-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-1,2,3-thiadiazole-5-carboxanilide
• Formule empirique (notation de Hill) : C₁₅H₉F₆N₅OS
• Numéro CAS: 223499-30-7
• Poids moléculaire : 421.32
• NACRES: NA.77
• PubChem Substance ID: 329831590
• UNSPSC Code: 12352200
• MDL number: MFCD00220976
• Assay: ≥98% (HPLC)
• Form: powder

Propriétés

• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: Cc1nnsc1C(=O)Nc2ccc(cc2)-n3nc(cc3C(F)(F)F)C(F)(F)F
• InChI: 1S/C15H9F6N5OS/c1-7-12(28-25-23-7)13(27)22-8-2-4-9(5-3-8)26-11(15(19,20)21)6-10(24-26)14(16,17)18/h2-6H,1H3,(H,22,27)
• InChI key: XPRZIORDEVHURQ-UHFFFAOYSA-N

Description

Application

YM-58483 has been used in the inhibition studies of calcium channels present in cardiomyocytes and pulmonary arterial endothelial cells.

Biochem/physiol Actions

Selective store operated calcium (SOC) channel inhibitor.

YM-58483 is a selective Ca⁺⁺ release-activated Ca⁺⁺ (CRAC) [a.k.a. store-operated Ca⁺⁺ (SOC) channels] that mediate Ca⁺⁺ influx in T cells and other inflammatory cells. CRAC channel inhibitors have potential clinical applications in autoimmune disease, transplant rejection, allergic airway inflammation and bronchial asthma. YM-58483 is also promoted as a tool for CRAC studies; may be used as a gold standard.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves