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T2943

Sigma-Aldrich

Tissue plasminogen activator chromogenic substrate

≥95% (HPLC), solid

Synonyme(s) :

TPA Activity Assay

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About This Item

Numéro MDL:
MFCD03458748
Code UNSPSC :
12352204
Nomenclature NACRES :
NA.32

Niveau de qualité

200

Essai

≥95% (HPLC)

Forme

solid

Poids mol.

apparent mol wt 658.9

Solubilité

methanol: water (1:9): 25 mg/mL

Température de stockage

2-8°C

Catégories apparentées

Description générale

Tissue plasminogen activator chromogenic substrate is a highly sensitive chromogenic peptide substrate for tissue plasminogen activator (tPA). It shows different sensitivity to native single-chain tPA (sc-tPA) and its fully active two-chain form (tc-tPA).

Application

Tissue plasminogen activator chromogenic substrate has been used:
  • in tissue plasminogen activator inhibition assay
  • to determine the plasminogen activator (PA) activity by studying the glycosylation properties of tissue plasminogen activator (tPA) activities in effusions using concanavalin A-Sepharose (conA-S) chromatography
  • in inhibition assays and complex formation analyses of wild type (WT) neuroserpin (NS) and its variants

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
0000298608
0000298608
0000259155
0000262293
0000262293

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Mahdieh Bayat et al.
Journal of biotechnology, 280, 1-10 (2018-05-29)
The aim of the present study was to investigate the effect of three routine drug excipients, as osmolytes, in three different concentrations, on structure, thermal stability and the activity of single-chain (sc-) tenecteplase. To see the influence of trehalose, mannitol
Shadabi Bano et al.
IUBMB life, 72(10), 2180-2193 (2020-08-23)
Heparin cofactor II (HCII) is predominantly expressed in the liver and inhibits thrombin in blood plasma to influence the blood coagulation cascade. Its deficiency is associated with arterial thrombosis. Its cleavage by neutrophil elastase produces fragment that helps in neutrophil
Mark W C Hatton et al.
The Journal of laboratory and clinical medicine, 147(1), 27-35 (2006-01-31)
The VX2 tumor is derived from a papilloma virus-induced rabbit epithelial cell line. If VX2 tumor cells (trapped in a plasma clot) are introduced intravenously into NZW rabbits, the cells lodge in the lung capillary bed and produce tumors. Independently
Mahdieh Bayat et al.
International journal of biological macromolecules, 130, 863-877 (2019-03-09)
Organic osmolytes, as major cellular compounds, cause protein stabilization in the native form. In the present study, the possible chaperone effects of the three naturally occurring osmolytes on the two-chain form of tenecteplase (tc-TNK), a recombinant, genetically engineered mutant tissue
Jesse Cahill et al.
Frontiers in molecular biosciences, 7, 574477-574477 (2020-10-08)
Although chemically inert, Xe and other noble gases have been shown to have functional effects on biological systems. For example, Xe is a powerful anesthetic with neuroprotective properties. Recent reports have claimed that Xe inhibits the activity of tissue plasminogen
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