T133
Inactin® hydrate
≥98% (HPLC), Anethetic reagent, powder
Synonyme(s) :
Thiobutabarbital sodium salt hydrate
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A propos de cet article
Formule empirique (notation de Hill) :
C10H15N2NaO2S · xH2O
Numéro CAS:
Poids moléculaire :
250.29 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
213-425-3
MDL number:
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Inactin® hydrate, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
drug control
USDEA Schedule IIIN; regulated under CDSA - not available from Sigma-Aldrich Canada
color
light yellow
solubility
H2O: soluble (storage of solutions for more than 8 hours at 4°C is not recommended.)
SMILES string
[Na+].CCC(C)C1(CC)C([O-])=NC(=S)NC1=O
InChI
1S/C10H16N2O2S.Na/c1-4-6(3)10(5-2)7(13)11-9(15)12-8(10)14;/h6H,4-5H2,1-3H3,(H2,11,12,13,14,15);/q;+1/p-1
InChI key
SLZHLQUFNFXTHB-UHFFFAOYSA-M
Application
Inactin® hydrate has been used to anesthetize rats to study stress-induced hypersensitivity and mice to study Cisplatin-induced neuropathy. It has also been used to anesthetize rats to measure the glomerular filtration rate (GFR).
Biochem/physiol Actions
Inactin® is a long-lasting rodent anesthetic with minimal effects on cardiovascular tone and renal output. It exhibits sedative and hypnotic properties.
Legal Information
Inactin is a registered trademark of Merck KGaA, Darmstadt, Germany
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Eman Y Gohar et al.
Journal of the American Heart Association, 9(10), e015110-e015110 (2020-05-12)
Background The novel estrogen receptor, G-protein-coupled estrogen receptor (GPER), is responsible for rapid estrogen signaling. GPER activation elicits cardiovascular and nephroprotective effects against salt-induced complications, yet there is no direct evidence for GPER control of renal Na+ handling. We hypothesized
J Buelke-Sam et al.
Laboratory animal science, 28(2), 157-162 (1978-04-01)
Rats were anesthetized with pentobarbital, pentobarbital and atropine, inactin [5-ethyl-5-(1'-methyl-propyl)-2-thiobarbiturate], ether and inactin, or urethane. Cardiovascular and arterial acid-base parameters were monitored over a 3-hour period of anesthesia. Heart rate, arterial pressures, and pH progressively decreased with duration of pentobarbital
Haiyun Qi et al.
Magnetic resonance in medicine, 80(5), 2073-2080 (2018-03-10)
Anesthesia is necessary for most animal studies requiring invasive procedures. It is well documented that various types of anesthesia modulate a wide variety of important metabolic and functional processes in the body, and as such, represent a potential limitation in
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| SAB1306335-400UL | 04061835642977 |
| T133-5X1G | 04061832561295 |
| T133-1G | 04061826203996 |
| T133-25X1G | 04061837337178 |