SML3642

PD 173955

≥98% (HPLC)

• Synonyme(s) : 6-(2,6-Dichlorophenyl)-8-methyl-2-[[3-(methylthio)phenyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one, PD-173955
• Formule empirique (notation de Hill) : C₂₁H₁₆Cl₂N₄OS
• Numéro CAS: 260415-63-2
• Poids moléculaire : 443.35
• UNSPSC Code: 12352200
• NACRES: NA.25
• MDL number: MFCD16038305
• Assay: ≥98% (HPLC)
• Form: powder

Propriétés

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (warmed)
• storage temp.: -10 to -25°C
• SMILES string: S(C)c1cc(ccc1)Nc2nc3c(cn2)C=C(C(=O)N3C)c4c(cccc4Cl)Cl
• InChI: 1S/C21H16Cl2N4OS/c1-27-19-12(9-15(20(27)28)18-16(22)7-4-8-17(18)23)11-24-21(26-19)25-13-5-3-6-14(10-13)29-2/h3-11H,1-2H3,(H,24,25,26)
• InChI key: VAARYSWULJUGST-UHFFFAOYSA-N

Description

Biochem/physiol Actions

PD 173955 is Tyrosine kinase inhibitor (TKI), which potently inhibits Bcr-Abl (IC50 = 1-2 nM), Src family kinase inhibitor specific for Src and Yes kinases (IC50 of 22 nM), and MAPK6/ERK3. According to IUPHAR/BPS Guide to PHARMACOLOGY PD 173955 is a best standard MAPK6 inhibitor pKD = 6.8

Tyrosine kinase type I inhibitor; potently inhibits Bcr-Abl and MAPK6/ERK3; Src family kinase inhibitor specific for Src and Yes kinases

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable